biologics Flashcards
1
Q
chimeric monoclonal ab
A
infliximab
2
Q
human recombinant ab
A
adalimumab, golimumab
3
Q
Human recombinant receptor, Fc fusion
A
etanercept
4
Q
Human Fab with PEG
A
Certolizumab
5
Q
Infliximab
A
binds TNF-alpah
6
Q
What do you give with infliximab and why
A
MTX to inhibit HACAs
7
Q
what does damage correpond with in RA progression
A
at first inflammation then radiographs
8
Q
etanercept mech
A
soluble fusion protein so it binds soluble and cell-bound TNF
9
Q
why isnt IL1 antagonism effective
A
you have to block all the receptors
10
Q
Tocilizumab
A
blocks IL-6. use if anti-TNF fails
11
Q
Rituximab
A
chimeric anti-CD20 MAB. B cell apoptosis. Use if anti TNF fails
12
Q
Abatacept
A
aka CTLA4. Displaces CD28 and binds to CD80/86
13
Q
Tofacitinib
A
inhibitor of JAKs
