inflammatory myopathies

Question 1

which inflammatory myopathies are auto immune and which are not

Answer 1

Auto: polymyositis, dermatomyositis. Not: inclusion body myositis

Question 2

characteristics of weakness and pain in myopathies

Answer 2

proximal (-inclusion body) and relative lack of pain

Question 3

labs typical of myopathies

Answer 3

elevated creatine kinase (CK). EMG abnormalities. High ESR

Question 4

If its a polymyositis with lung involvement think___

Answer 4

anti Jo-1 antibody

Question 5

pathology of polymyositis

Answer 5

inflammation around normal muscle fibers. Nuclei move from external to internal

Question 6

Tx of polymyositis and dermatomyositis

Answer 6

corticosteroid like prednisone

Question 7

dermatomyositis

Answer 7

dysphagia, erythema, eczema on extensor surface of joints

Question 8

juvenile dermatomyositis

Answer 8

skin problems plus contracture of ankles (toe walking), possible vasculitis

Question 9

dermatomyositis pathology

Answer 9

MAC at normal capillaries (perivascular inflamm). Perifasicular atrophy (pathognomonic)

Question 10

inclusion body myositis

Answer 10

distal weakness, asymmetry, insidious onset of wrist and finger flexors

Question 11

pathology of IBM

Answer 11

rimmed vacuoles