NSAIDS

Question 1

injury to tissue specific PGs

Answer 1

injury>phospholipids, Phospholipase A2 converts to Arachidonic acid. COX converts to PGH2 which is converted to tissue specific PG

Question 2

COX1 vs COX2

Answer 2

housekeeping; inflammatory

Question 3

celebrex (celecoxib)

Answer 3

COX2 specific inhibitor. Still affects kidney but not GI tract and not platelets

Question 4

allodynia

Answer 4

touch causes pain (sunburn) (periphery)

Question 5

hyperalgesia

Answer 5

pain is amplified (poke sunburn with pin) (central)

Question 6

Are NSAIDs analgesics

Answer 6

They are anti-hyperalgesics. Cut hurts just as much but afterward not as much

Question 7

how do you reduce ulcers from NSAIDS?

Answer 7

give a PPI or MISOPROSTOL (increases mucus formation. Causes diarrhea

Question 8

how do NSAIDS affect kidney? which COXs?

Answer 8

COX1 &2. BP elevation in pts treated for htn and necrosis in pts with reduced renal flow

Question 9

what cox do platelets have? haw does it make?

Answer 9

COX1. forms thromboxane A2

Question 10

how does aspirin have such a long effect on platelets

Answer 10

no cell nucleus means no more COX so its inhibition is irreversible.

Question 11

Reye’s syndrom

Answer 11

dont give ASA to kids with viral illness. you get seizures, coma, death

Question 12

Acetaminophen actions

Answer 12

not anti-inflammatory. Decent antipyretic and analgesic

Question 13

toxicity of acetaminophen

Answer 13

liver

Question 14

go back over NSAID names

Answer 14

motrin, naprosyn, indocin, diclofenac (voltaren), nabumetone (relafen), ketorolac (toradol), mobic (meloxicam)

Question 15

ketorolac

Answer 15

IV

Question 16

NSAIDS are ideal for

Answer 16

perioperative use (no ileus but causes bleeding), incident pain