Bone infections

Question 1

Most common bacterial pathogen in septic arthritis? How does it attach? Second most common?

Answer 1

staph aureus. MSCRAMMs. N. gonorrhoeae

Question 2

joint destruction in septic arthritis caused by?

Answer 2

endotoxins and inflammation

Question 3

complications of limb ischemia

Answer 3

increased intra-articular pressure. ischemia and necrosis

Question 4

septic arthritis pathogens in adults with diabetes/cancer? neonates? IV drug users

Answer 4

strep agalactiae; e coli; pseudomonas

Question 5

causative agent in lyme dz? Vector?

Answer 5

Borrelia burgdorferi. tick. erythema migrans, arthritis, palsy

Question 6

Joints involved in septic arthritis

Answer 6

knee. monoarticular

Question 7

septic arthritis labs

Answer 7

WBC>50,000, >90% PMNs

Question 8

triad of gonococcal arthritis. Who gets it?

Answer 8

tenosynovitis, dermatitis, polyarthralgia. More common in women (have more asymptomatic infections)

Question 9

causative agent in viral arthritis. What type of arthritis

Answer 9

human parvovirus B19. Acute, symmetrical polyarthritis

Question 10

Osteomyelitis: pathogenesis/organism/bones in adults? kiddos?

Answer 10

Adults: hematogenous, monobacterial., long bones and spine. Kids: contiguous, polymicrobial, foot and sacrum

Question 11

survival of pathogens in osteomyelitis

Answer 11

adherence to damaged bone (MSCRAMMs), live w/in osteoblasts (dormancy explains relapse rate), biofilm formation

Question 12

most common causative agent in osteomyelitis

Answer 12

staph aureus.

Question 13

imaging of osteomyelitis diagnosis

Answer 13

CT, MRI

Question 14

which type of osteomyelitis is urgent?

Answer 14

vertebral.

Question 15

Potts Dz

Answer 15

vertebral osteomyelitis due to TB

Question 16

Pathogenesis of OM in diabetics

Answer 16

neuropath and vasculopathy lead to skin ulcers. Contiguous infection of bone

Question 17

treatment of septic arthritis

Answer 17

drain fluid and antibiotics