Sepsis and Septic Shock

Question 1

Define systemic inflammatory response syndrome (SIRS).

Answer 1

Response of the body systemically

• infection could be in blood or tissue
• could be do to an infection

Criteria:
Any 2 of the following
-fever of more than 38 degrees (or less than 36)
- heart rate > 90
- respiratory rate >20 breaths more minute
- abnormal WBS >12000/ul
- bands (immature neutrophil)

Question 2

What is normal WBC?

Answer 2

4,000 - 10,000 / cmm

Question 3

What is a band cell?

Answer 3

• immature neutrophil

- band cells increase in blood when need for neutrophils exceeds bone marrow’s ability to produce them

Question 4

What is the acute phase response?

Answer 4

Release of various proteins from liver in response to stimulation with IL-6 and other pro-inflammatory cytokines

Question 5

What is sepsis?

Answer 5

SIRS due to a documented infection

Question 6

What is severe sepsis?

Answer 6

sepsis with organ dysfunction
ex) elevated BUN, createnine, urinary problems

nonresponsive - organ dysfunction

Question 7

What is septic shock?

Answer 7

infection-induced Hypotension and cannot be reversed with IV fluid

Question 8

What is disseminated intravascular coagulation (DIC)?

Answer 8

systemic activation of clotting system followed by depletion of clotting factors and subsequent systemic hemorrhage

Question 9

What is multiorgan dysfunction syndrome?

Answer 9

varying degrees of organ impairment secondary to SIRS

Question 10

What is compensatory anti-inflammatory response syndrome (CARS)?

Answer 10

unregulated anti-inflammatory response leading to immune suppression & increased risk of infection