Segundos mensajeros Flashcards

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1
Q

Enzima que degrada al AMPc

A

AMPc fosfodiesterasa

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2
Q

La síntesis de AMPc es a partir de →

A
  • Adenilato ciclasa
  • ATP
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3
Q

PKA

A

Proteína dependiente de AMPc

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4
Q

EPAC

A

Proteína de intercambio activada directamente por AMPc

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5
Q

Sistema de la adenilato ciclasa

A

Adenilato ciclasa → AMPc → EPAC + PKA → PKA libera cinasa → CREB

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6
Q

Funciones del AMPc

A
  • Metabolismo
  • Expresión de genes
  • División celular y crecimiento
  • Diferenciación celular
  • Neurotransmición
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7
Q

Enzima que degrada al GMPc

A

Fosfodiesterasa

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8
Q

Sistema de guanilil ciclasa

A

Guanilil ciclasa → GTP → GMPc → PKG

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9
Q

Sistema de fosfolípidos

A

Receptor acoplado a proteína G → PLC-beta → Fosfatidilinositol-4,5-bifosfáto → IP3 +DAG
DAG → PKC (secreción celular y expresión de genes)
IP3 → PKB o AKT

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10
Q

PKB

A
  • Factores de transcripción
  • Metabolismo celular
  • Síntesis de proteínas
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11
Q

AKT 1-3

A

1 → Inhibe apoptosis (hipertrófia muscular)
2 → señalización de insulina (ttansporte de glucosa)
3 → cerebro?

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12
Q

Vía del calcio

A
  • Señal eléctrica → química
  • Se una a calmodulina → activa cinasas
  • CREB
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13
Q

¿qué activa a RAS, RAF y MAPK?

A
  • Receptores acoplados a proteínas G
  • Receptores tirosin-cinasa
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14
Q

RAS

A

Proteína unida a GTP o GDP

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15
Q

RAF

A

Cinasas

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16
Q

MAPK

A

Cinasas que fosforilan serina/treonina

17
Q

JAK/STAT

A

JACK → cinasas janus
STAT → signal transducers and activators of transcription
JAK fosforila a STAT para que se conviertan a factor de transcripción

18
Q

```

~~~

Receptores adrenérgicos

A