Sedatives And Hypnotics 2 Flashcards
The SAR of barbiturates includes what
Modification at C-5
Modification at N
Modification at O
Explain the modification at C-5
Explain the modification at N
Explain the modification at O
What is the effect of sulfur substitution in barbiturates
Explain thiopental
What is the use of thiopental
Explain the toxicity of barbiturates
What is the classification of barbiturates
What are the clinical uses of barbiturates
What are barbiturates currently only used for?
Epilepsy and anesthesia
Why are barbiturates current,y only used for epilepsy and anesthesia
Benzodiazepines are clinically used for what
Why are benzodiazepines important
What is the prototype of benzodiazepines
Diazepam
What is Librax
Explain diazepam
Diazepam (1st generation - 3 rings)
Why are benzodiazepines used over barbiturates
What is the difference between first and second generation benzodiazepines
1st - 3 rings
2nd - 4 rings
Explain how benzodiazepines work
Benzodiazepines may cause what and where are they absorbed
Why some benzodiazepines are short acting and some long acting
If the metabolite is still active then the duration is longer
What are some important considerations for benzodiazepines
Explain the pharmacokinetics of benzodiazepines
Explain the metabolism of benzodiazepines
