Antiparkinsonism Flashcards
Explain the etiology of Parkinson’s disease
Explain the neuropathology of Parkinson’s disease
Explain dopamine receptors
Define dopaminergic pathways
What are the 5 dopaminergic pathways
Reduced dopaminergic activity produces what
Increased dopaminergic transmission produces what
What are the symptoms of Parkinson’s disease
Explain dopamine biosynthesis
What is the imbalance in Parkinson’s disease and how to treat it
List the strategy of treatment
What are the possible dopaminergic drugs
Why isn’t dopamine given to treat Parkinson’s disease
Why is L dopa used to treat Parkinson’s disease
It can cross BBB because it resembles amino acid so tricks the BBB
Uses the transporter of amino acid
Why is a large dose of L-Dopa given
Should L-Dopa be given with peripheral or central decarboxylase inhibitor ?
How to have more amount of L-Dopa reach the BBB
Give L-Dopa with decarboxylase inhibitor and COMT inhibitor
Explain the therapeutic effect of L-Dopa
What are the unwanted effects of L-Dopa
What are the drug interaction of L-Dopa
Explain the combination of L-Dopa + Carbidopa
Explain selegiline
Explain entacapone
