Antihypertensive Agents - Diuretics Flashcards by Лили Ауси

Q

What is the classification of diuretics

A

Carbonic anhydrase inhibitors
Thiazides
Thiazide like
Loop diuretics
Potassium sparing diuretics

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Q

What are diuretics

A

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Q

How do diuretics decrease blood pressure

A

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Q

What are the conditions treated by diuretics

A

Hypertension
Systemic edema
Glaucoma
Obesity

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Q

What is a side effect of carbonic anhydride inhibitor ?

A

Decrease bicarbonate so more acidic - lower blood pH causing metabolic acidosis

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Q

What is the mechanism of diuretics

A

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Q

Explain the mechanism of action of loop diuretics

A

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Q

Explain carbonic anhydrase

A

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Q

Explain carbonic anhydrase inhibitor

A

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Q

Are carbonic anhydrase inhibitors used as diuretics

A

They are weak diuretics - now used as local eye drops for glaucoma

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Q

Thiazide diuretics are derived from what and how do they work

A

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Q

Explain the side effects of thiazide diuretics

A

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Q

Explain the SAR of thiazide diuretics

A

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Q

Explain indapamide (natrilix)

A

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Q

A

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Q

Explain Furosemide

A

Q

Furosemide is clinically used for what

A

Q

What are the side effects of Furosemide

A

Q

A

Furosemide - furan

Q

What’s the difference between potassium sparing diuretics with the other types of diuretics

A

Q

Why are the potassium sparing diuretics called like that

A

Q

How are the potassium sparing diuretics used

A

Q

What is the side effect of potassium sparing diuretics

A

Hyperkalemia

Q

What should be avoided when taking potassium sparing diuretics

A

Food rich in potassium like banana

Q

Explain an example of potassium sparing diuretics

A

Q

Explain amiloride and how it is different from spironolactone

A

Amiloride inhibits sodium reabsorption in the late distal consulates tubule, it does not compete with aldosterone - it inhibits the transporter itself not the receptor

Q

A

Spironolactone - has spiral carbon