Antihypertensive Agents - Diuretics Flashcards

1
Q

What is the classification of diuretics

A

Carbonic anhydrase inhibitors
Thiazides
Thiazide like
Loop diuretics
Potassium sparing diuretics

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2
Q

What are diuretics

A
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3
Q

How do diuretics decrease blood pressure

A
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4
Q

What are the conditions treated by diuretics

A

Hypertension
Systemic edema
Glaucoma
Obesity

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5
Q

What is a side effect of carbonic anhydride inhibitor ?

A

Decrease bicarbonate so more acidic - lower blood pH causing metabolic acidosis

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6
Q

What is the mechanism of diuretics

A
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7
Q

Explain the mechanism of action of loop diuretics

A
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8
Q

Explain carbonic anhydrase

A
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9
Q

Explain carbonic anhydrase inhibitor

A
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10
Q

Are carbonic anhydrase inhibitors used as diuretics

A

They are weak diuretics - now used as local eye drops for glaucoma

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11
Q

Thiazide diuretics are derived from what and how do they work

A
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12
Q

Explain the side effects of thiazide diuretics

A
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13
Q

Explain the SAR of thiazide diuretics

A
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14
Q

Explain indapamide (natrilix)

A
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15
Q
A
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16
Q

Explain Furosemide

17
Q

Furosemide is clinically used for what

18
Q

What are the side effects of Furosemide

19
Q
A

Furosemide - furan

20
Q

What’s the difference between potassium sparing diuretics with the other types of diuretics

21
Q

Why are the potassium sparing diuretics called like that

22
Q

How are the potassium sparing diuretics used

23
Q

What is the side effect of potassium sparing diuretics

A

Hyperkalemia

24
Q

What should be avoided when taking potassium sparing diuretics

A

Food rich in potassium like banana

25
Explain an example of potassium sparing diuretics
26
Explain amiloride and how it is different from spironolactone
Amiloride inhibits sodium reabsorption in the late distal consulates tubule, it does not compete with aldosterone - it inhibits the transporter itself not the receptor
27
Spironolactone - has spiral carbon