Antihyperlipidemic

Question 1

What are the major lipids found in the bloodstream

Answer 1

Question 2

High lipid levels can do what

Answer 2

Speed up a process called atherosclerosis, or hardening of the blood vessels

Question 3

What is hyperlipoproteinemia

Answer 3

Question 4

hyperlipoproteinemia has been strongly associated with what

Answer 4

Question 5

What is the cause of hyperlipoproteinemia

Answer 5

Question 6

What is dyslipidemia

Answer 6

Question 7

What are the sources of cholesterol

Answer 7

Question 8

What is the rate limiting step of cholesterol biosynthesis

Answer 8

Question 9

What is the importance of HMG CoA Reductase

Answer 9

It is the target for drugs and if inhibited it will stop the whole synthesis of cholesterol

Question 10

Explain cholesterol

Answer 10

Question 11

Is cholesterol bad

Answer 11

Question 12

Explain cholesterol ester

Answer 12

Question 13

Triglycerides are formed from what

Answer 13

Question 14

Where does the pancreatic lipase acts

Answer 14

Question 15

Can lipids be absorbed ?

Answer 15

In triglyceride form, lipids can’t be absorbed by the duodenum, it should be hydrolyzed in the GIT to be absorbed
Monoglycerides and diglycerides are absorbed by the duodenum

Question 16

Explain lipoproteins and their function

Answer 16

Question 17

How are triglycerides and cholesterol esters are carried

Answer 17

Question 18

What are the different types of lipoproteins

Answer 18

Question 19

How does bile acid help in lipoprotein metabolism

Answer 19

Bile acid facilitates the absorption to the bloodstream

Question 20

Explain the normal metabolism of lipoproteins

Answer 20

LDL is being reuptaken by LDL receptor in the liver

Question 21

What will happen if LDL receptor is not working

Answer 21

Question 22

Why do healthy people have high amounts of HDL

Answer 22

It will make the cholesterol be taken back to liver, to be used in synthesis
Preventing atherosclerosis - acts as protective mechanism

Question 23

What are the drug targets to treat hyperlipidemia

Answer 23

Question 24

Explain low density lipoproteins

Answer 24

Question 25

Explain high density lipoproteins

Answer 25

Question 26

How is diagnosis of lipoproteins made

Answer 26

Question 27

Answer 27

Question 28

List the antihyperlipidemic agents

Answer 28

Question 29

Why is nicotinic acid not preferred

Answer 29

Question 30

What does nicotinic acid do

Answer 30

Question 31

What is the first drug choice for patients with elevated LDL

Answer 31

HMG-CoA reductase inhibitors

Question 32

What is the mechanism of HMG-CoA reductase inhibitors

Answer 32

Question 33

The inhibition of HMG-CoA reductase results in what

Answer 33

Question 34

What are the 2 main classes of HMG-CoA reductase inhibitors

Answer 34

Question 35

What is statins mechanism of action

Answer 35

Question 36

What type of inhibitor is statin

Answer 36

Competitive as it has similar structure to the substrate

Question 37

Answer 37

Question 38

Explain the SAR of statins

Answer 38

Question 39

Explain the physiochemical properties of statins

Answer 39

Question 40

Explain the side effects of all statins

Answer 40

Question 41

Explain fibrates

Answer 41

Question 42

Explain the main effect of fibrates

Answer 42

Question 43

Fibrates facilitate lipid metabolism resulting in what

Answer 43

Question 44

Explain ezetimibe

Answer 44

Question 45

How does ezetimibe work

Answer 45

Question 46

How are ezetimibe used

Answer 46

Question 47

Explain bile acid sequestrants

Answer 47

Question 48

Explain the mechanism of bile acid sequestrants

Answer 48