Antiepileptic Drugs Flashcards by Лили Ауси

Q

What is the classification of seizures

A

Partial/focal seizures (localized)
Generalized seizures (distributed)

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Q

Example of partial seizures

A

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Q

Example of generalized seizures

A

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Q

Explain tonic phase of seizure

A

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Q

Explain clonic phase of seizures

A

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Q

Explain absence seizures

A

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Q

Explain myoclonic seizures

A

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Q

Explain atonic seizures

A

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Q

Explain status epilepticus

A

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Q

A

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Q

Explain EEG

A

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Q

What does EEG do

A

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Q

What is the main diagnostic application of EEG

A

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Q

How do seizures happen

A

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Q

How to treat seizures

A

Increase GABA
Decrease activity of glutamate

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Q

How is GABA formed

A

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Q

What are the strategies for Antiepileptic drugs

A

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Q

Ideal antiepileptic drugs should

A

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Q

Chemically antiepileptic drugs can classified into what

A

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Q

What are the first generation antiepileptic drugs

A

Hydantoins
Barbiturates
Oxazolidinedione
Succinimides
Carboxylic acid
Carbamazepine
Benzodiazepines

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Q

Hydantoins include what

A

Phenytoin
Fosphenytoin

Q

Explain Phenytoin

A

Q

What is the mechanism and pharmacokinetics of phenytoin

A

Q

Explain phenytoin toxicity

A

Q

Explain fosphenytoin

A

Q

What is clinical use of fosphenytoin

A

Status epilepticus

Q

What are the barbiturates used for epilepsy

A

Phenobarbital
Primidone

Q

Explain phenobarbital

A

Q

Explain the pharmacokinetics and metabolism of phenobarbital

A

Q

What are the side effects of phenobarbital

A

Q

Explain primidone

A

Q

Explain oxazolidinedione

A

Q

Explain succinimides with examples

A

Q

Example of carboxylic acid used for epilepsy

A

Valproic acid

Q

Exaplin valproic acid

A

Q

Explain the toxicity, side effects and drug interactions of valproic acid

A

Q

Explain carbamazepine

A

Q

Explain metabolism of carbamazepine

A

Q

Explain the toxicity, side effects and drug interactions of carbamazepine

A

Q

Explain benzodiazepines for epilepsy

A

Q

Explain clonazepam

A

Q

What are the other drugs used for epilepsy

A

Lamotrigine
Topiramate
Gabapentin
Pregabalin

Q

Explain lamotrigine and its mechanism

A

Q

What are the side effects of lamotrigine

A

Q

What is topiramate

A

Q

What are the clinical uses of topiramate

A

Q

What is the mechanism of action of topiramate

A

Q

Explain gabapentin

A

Q

What is the clinical use of gabapentin

A

Q

Explain metabolism of gabapentin

A

Not metabolized and excreted unchanged in urine

Q

Explain pregabalin

A