Sedatives And Hypnotics 1 Flashcards

1
Q

Define sedative

A
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2
Q

Define hypnotic

A
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3
Q

Define anxiolytic

A
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4
Q

Sedatives and hypnotics at very low dose will be what

A

Anxiolytic

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5
Q

Explain the sedative hypnotic drug dose dependent depression of the CNS

A
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6
Q

What are the two general classes of neurotransmitters

A

Biogenic amines
Amino acids

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7
Q

Examples of biogenic amines

A
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8
Q

Examples of amino acids

A
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9
Q

Is acetylcholine a biogenic mineral or amino acid

A
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10
Q

What are the 2 kinds of post synaptic receptors

A

Ionitropic / ligand gated ion channels
Metabotropic/ G-protein coupled

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11
Q

What are the neurotransmitters in ligand gated ion channels

A
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12
Q

What are the neurotransmitters for G protein coupled

A
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13
Q

What are the classification of sedative hypnotics

A
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14
Q

What is the major inhibitory neurotransmitter

A

GABA

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15
Q

How do benzodiazepines work

A
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16
Q

How do barbiturates work

17
Q

Can barbiturates and benzodiazepines be given together

18
Q

What have the most powerful effect on the CNS that the other sedatives

A

Barbiturates

19
Q

What effect does barbiturates have in different doses

A

Low dose - calming effect
Moderate dose - drunken euphoric state (like alcohol)
High dose - sedation and sleep occur
Very high dose - surgical, anesthesia

20
Q

Barbiturates were popular in the treatment of what

21
Q

Why are barbiturates rarely used

22
Q

Explain benzodiazepines

23
Q

What’s a similarity between benzodiazepines and barbiturates

A

Anticonvulsant effects

24
Q

What is the use of benzodiazepines

25
Q

Explain the mechanism of barbiturates and benzodiazepines

26
Q

Explain GABA

27
Q

How does GABA produce its effect

28
Q

Why is barbiturates called an acid

A

Because of tautomerism

29
Q

What is needed for barbiturates

A

Little acidity
Position 5 disubstitution
Lipophilicity