schizophrenia drugs Quetiapine Flashcards
1
Q
what is Quetiapine uses
A
antipsychotic
2
Q
what is Quetiapine effective against
A
Eective against +ve and -ve symptoms
3
Q
what does it do
and what does it bind to
A
Competitive antagonism
dopamine D2 and 5HT2A receptors
4
Q
where does it bind to dopamine / serotonin receptors
A
mesolimbic/mesocortical
pathways
5
Q
it also has antagonism of
A
H1 receptors
6
Q
what does antagonism of H1 underlie
A
sedative action
7
Q
what are the clinical uses of Quetiapine
A
Schizophrenia and other psychotic states.
Bipolar disorder.
8
Q
what are the adverse effects
8 answers
A
Weight gain. Minor EPS and hyperprolactinaemia. Sedation. Postural hypotension. Constipation, dry mouth (antimuscarinic actions). Rarely, neuroleptic malignant syndrome.
