affective disorders MAOi Phenelzine Flashcards
1
Q
what does Phenelzine do and what is its MOA
A
antidepressant
irreversibly inhibits MAO- a and b
which increase NT in synapses as there is continuous release and no break down
2
Q
what do MAO-a
and MAO-b do
A
A) acting on Nor and 5-HT
B) dopamine
3
Q
what is its half life and what does it cause
A
1-2h
lasting effect because binding is irreversible
4
Q
clinical uses
A
depression
social phobia
5
Q
adverse effects
A
postural hypotension
insomnia
sexual dysfunction
cheese reacts with tyramine = hypertensive crisis
6
Q
the adverse effects are more
A
frequent then in tca or SSRI
7
Q
what does this drug increase (side effect)
A
risk of young patients committing suicide
