schizophrenia drugs Aripiprazole

Question 1

what are the uses of Aripiprazole

Answer 1

antipsychotic

Question 2

what is Aripiprazole effective against

Answer 2

E†ective against +ve and -ve symptoms

Question 3

where does it bind to

3 answers

Answer 3

strongly to dopamine D2 receptors
but has partial agonist activity
5HT2A antagonism

Question 4

what does the partial agonist activity explain

Answer 4

its low

incidence of EPS.

Question 5

what are the clinical uses of Aripiprazole

Answer 5

Schizophrenia and other psychotic states.

Manic phase of bipolar disorder.

Question 6

adverse effects

Answer 6

Fewer side e†ffects than many other antipsychotics (e.g. minor EPS (some akathisia), less weight gain,
less antimuscarinic, less prolactin secretion).
Some hypotension and nausea & vomiting.