affective disorders alpha/5-HT antagonism Mirtazapine Flashcards
1
Q
what is Mirtazapines use and MOA
A
antidepressant
antagonist of presynaptic alpha 2
which prevents inhibitory effects of NOR on 5-HT
also Nor release from CNS neuron
thus enhancing monoaminergic transmission
2
Q
more specifically for 5-HT what is being inhibited
A
antagonism of 5-HT2 and 3 receptors
3
Q
what does inhibition of 5-HT help with
A
reduces the side effects due to potentiation of seratonin
eg sexual dysfunction
4
Q
clinical uses
A
major depression
post traumatic stress disorder
5
Q
adverse effects
A
antihis action = sedation
increased appetite
weight gain
agranulocytosis
6
Q
why is antihistaminergic action useful
A
useful in patients who have both insomnia and depression
eg sedation
