schizophrenia drugs haloperidol Flashcards
1
Q
what are the 1st gen antipsychotics
A
chlorpromazine
haloperidol
Flupentixol
2
Q
haloperidol actions
A
antipsychotic
apathy
reduced aggression
antiemetic
3
Q
haloperidol MOA
A
Competitive antagonism of dopamine D2 receptors.
4
Q
haloperidol MOA where
A
in the mesolimbic/mesocortical pathways.
5
Q
haloperidol MOA clinical benifits
A
delayed although receptor block is immediate, suggesting that more complex
changes in neurotransmission occur.
6
Q
haloperidol MOA potency compared to chlorpromazine
A
Higher potency
7
Q
haloperidol clinical uses
A
schiz - less effective against -ve
mania
aggressive behaviour
tourettes syndrome
8
Q
haloperidol adverse effects
A
marked EPS (dystonias and Parkinsonian symptoms)
hyperprolactinaemia (inc levels of prolactin)
antimuscurinic action
neuroleptic malignant syndrone
