Affective disorders TCA amitriptyline

Question 1

what does it do and what’s its MOA

Answer 1

antidepressant
inhibits reuptake of nor and 5-HT to
noradrenergic and serotonergic neurons

Question 2

clinical effect of amitriptyline

Answer 2

not seen for a few weeks

long term change (eg down re of receptor)

Question 3

clinical uses of amtriptyline

Answer 3

depression
panic disorder
neuropathic pain

Question 4

adverse effects

Answer 4

urinary retention (antimusc)
postural hypotension (alpha 1 antagonism)
sedation (antihis)
dry mouth (anticholinergic)

Question 5

what is amitriptyline not given with

Answer 5

MAOi

increases risk of suicide in younger patients