affective disorder SSRI Fluoxetine Flashcards
1
Q
what does FLuoxetine do and what is its MOA
A
antidepressant
inhibits reuptake 5-HT
2
Q
what are the clinical effects of fluoxetine
A
Antid action not seen for a few weeks
because longer term changes (eg down reg of receptors)
3
Q
what does this SSRI have thats better then the TCA
A
less marked antihistaminergic and antimuscurinic action
4
Q
what are the clinical uses
A
depression (widely perscribed)
OCD
panic disorder
5
Q
adverse effects
A
anxiety and insomnia
sexual dysfunction
inc- risk of suicide in younger patients
hyponatraemia in elderly
6
Q
what is its overdoes toxicity compared to TCA
A
lower
7
Q
what is it not perscribed with
A
MAOi
risk of serotonin syndrome
