Schizophrenia and Psychotic Disroders Flashcards

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1
Q

What is psychosis?

A

A symptom not a disease, severe disease of the mind

Lack of insight

Inability to distinguish between symptoms of delusion, hallucinations and disorders thinking from reality

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2
Q

What is neurosis?

A

Disease of the nerves

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3
Q

Elevated mood with psychosis?

A

Manic, cannot be hypomanic with psychosis.

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4
Q

How can psychosis present clinically

A
Hallucinations- have the full force and clarity of true perception 
Located in external space
Not external stimulus 
Not willed or controlled
Happens in all 5 senses
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5
Q

What is a delusional belief

A

A delusion of unshakeable idea of belief which is out of keeping with the persons social and cultural background.

Grandiose
Paranoid
Hypochondrial
Self referential

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6
Q

What diseases typically exhibit psychosis

A

Physical Pathologies- e.g. brain disease

Schizophrenia

Delirium

Severe affective disorder

Depressive episodes with psychotic symptoms
Manic episodes with psychotic symptoms

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7
Q

What is schizophrenia

A

A severe mental illness affecting thinking, emotion and behaviour
It is the most common psychosis

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8
Q

What are the symptoms of schizophrenia

A

Positive- ( more likely to be disease and prognostically better)

Hallucinations
Delusions
Disordered thinking

Negative (less likely to have it and a worse prognosis)

Apathy
Lack of interest
Lack of emotions

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9
Q

What is the criteria for schizophrenia diagnosis

A

For more than a month one of the following must be had:

Alienation if thought (echoed thought, thought inserted into head, thought taken out of head, thought broadcasting)

Delusions of control, influenced of passivity(unable to control body), clearly referred to body or limb movements, sensations, delusional perception

Hallucinatory voices giving a running commentary on the patients behaviour or discussing him between theme selves, or other types of hallucinatory voices coming from some part of the body

Persist and delusions, culturally delusional or completely impossible beliefs

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10
Q

What is the sub criteria diagnosis for schizophrenia

A

One of the previous things plus two of the following

Persistent hallucinations in any modality, when occurring every day for at least one month

Neolgisms, breaks or interpolations on the train of thought,sitting in incoherence or irrelevant speech

Catatonic behaviour, such as excitements, posturing or waxy flexibility, negativism, mustism and stupor

Negative symptoms such as marked apathy paucity of speech and blunting or incongruity of emotional responses

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11
Q

What causes psychosis?

A

Biological factors
Psychological factors
Social factors
Evolutionary theories

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12
Q

What biological factors may cause schizophrenia

A

GWAS studies have showed:

Heritability between twins and families
Neuregulin and dysbindin are proteins that are thought to be lin,Ed to schizophrenia
DI George syndrome

Neurochemistry:

Dopamine hypothesis
Glutamate
GABA
serotonin pathways

Obstetric complications
Maternal influenza 
Malnutrition and famine
Winter
Substance misuse (high THC)
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13
Q

What are the psychological theories surrounding psychosis? (Not finished)

A

Collective unconscious from the past causes schizophrenia?

Process (Conrad 1958)

State of fear
Delusional idea appears
An effort to make sense of the experience causes a change in ones brain
Final change

Harland (2004)

Recognises gross excess of schizophrenia in migrants
All individuals construct a sense of self within framework of time, morality and cultural symbols
When changing location this has neuronal implications leading to vulnerability and severe mental illness

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14
Q

What is the social ideas of schizophrenia

A

Occupation and social class but be aware of drift hypothesis

Migration

Social isolation

Life events are precipitants (NO implications of cultural factors)

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15
Q

What are the theories around Psychosis and families

A

High expressed criticism is a predisposing factor to schizophrenia?

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16
Q

What are the differentials for psychosis

A

Delirium
Psychosis - consequent upon brain or systemic disease
Prominent visual experience, hallucinations and illusions
Affect of terrif
Delusions and persecutory and dvanscent
Fluctuating, worse at night

17
Q

What is affective psychosis?

A

Depressive episodes with psychotic symptoms
Delusions of guilt, worthlessness and persecution
Derogatory auditory hallucinations

Manic episodes with manic symptoms
Delusions of grandeur
Gross over activity, irritability,

18
Q

What is schizoaffective disorders

A

Mix of affective and schizophrenia like features

19
Q

How do you manage schizophrenia?

A

Earlier the intervention the better

Duration of untreated psychosis, the worse the prognosis

20
Q

How do you manage the adverse effects of schizophrenia treatment

A

See that green table at the bottom of the slide……

If pregnant review treatment as it may age negative effect on fetus

21
Q

How do you treat those with treatment resistant schizophrenia

A

Clozapine

22
Q

What psychological therapies can you use for schizophrenia?

A
Cognitive behavioural therapy 
Cognitive remediation
Family intervention
Social skills training
Relapse prevention
23
Q

What is the prognosis of schizophrenia like?

A

Recovery is not simply a reduction of abatement of symptoms

“Being able, to live a meaningful and satisfying life as defined by each son, in the presence or absence of symptoms”

80% recover after first episode of psychosis.

Early intervention is better.

Small group with chronic symptoms and little recovery

24
Q

Why are good prognostic factors in schizophrenia

A
Absence of big genetic load
Stable personality
Stable relationships
Precipitating factor
Acute onset
Mood disturbance 
Prompt treatment
25
Q

What are the poor prognosticat factors of schizophrenia

A

Slow, insidious onset and prominent negative symptoms, are associated with a worse outcome
Mortality is 1.6 times higher than general population
Shorter life expectancy is linked to cardiovascular disease, respiratory disease and cancer
Suicidal risk is 9 times higher
Death from violent incidents is twice as high
36% have a substance misuse problem and there are high rates of smoking
Childhood psychosis

26
Q

What are the take home messages about psychosis

A

Symptom not a diagnosis

What is a hallucination

What is a delusions

Delirium, schizophrenia and the affective psychoses are the principal illness