Sample Questions from class Exam 2 Flashcards
holstein cattle and irish setter dogs have mutations in which molecules to develop leukocyte adhesion deficiency?
a. selectin
b. ICAM1
c. Integrin (CD18)
d. PECAM-1 (CD31)
e. siayl-lewis X glycoprotein
C. integrin
histamine increases vascular permeability at the level of capillaries and venules through the mechanism of
a. endothelial cell contraction
b. endothelial cell damage
c. increased transcytosis
d. induces endothelial proliferation
a. endothelial cell contraction
an inflammatory cell that is long lived, can divide locally in tissue and regulates immune and repair responses
a. neutrophil
b. eosinophil
c. macrophage
d. platelet
e. B and C
c. macrophage (only cell that can divide locally in tissue!)
Neutrophil-endothelial surface molecules mediating “rolling”
a. integrin (CD11/CD18) - Selectin
b. sialyl lewis X - selectin
c. integrin (CD11/CD18) - ICAM1
d. PECAM1 (CD31) - PECAM1 (CD31)
B. sialyl lewis X - selectin
suppurative inflammatory reactions are often induced by
a. fungi
b. nematode parasites
c. bacteria (non-mycobacteria)
d. mycobacteria
e. toxins
c. bacteria (non-mycobacteria)
eosinophilic inflammatory reactions are often induced by
a. fungi
b. nematode parasites
c. bacteria (non-mycobacteria)
d. mycobacteria
e. toxins
b. nematode parasites
macrophage dominated (granulomatous) inflammatory reactions are often induced by:
a. fungi
b. nematode parasites
c. bacteria (non-mycobacteria)
d. mycobacteria
e. toxins
A and D. mycobacteria and fungi
which type of inflammatory cell is often associated iwth liquefactive necrosis?
a. lymphocyte
b. neutrophil
c. macrophages
d. eosinophil
e. mast cell
b. neutrophils (most effective at killing bacteria during acute infections)
which of the followign have potenet chemotactic activity for neutrophils? a. C5a b. LTB4 C. IL8/CXCL8 D. A, B, C E. B, C
D. All of them
which of the followign are potent mediators of increased vascular permeabilty? a. IL8/CXCL8 B. LTB4 C. Bradykinin D. LTC4, LTD4, LTE4 E. A, C, D F. C, D
F. bradykinin and LTC4, LTD4, LTE4
which of the following mediate pain perception? a. PGE2 b. LTB4 C. Bradykinin D. A, B, C E. A, C
E. PGE2 and Bradykinin
inciting stimuli of granulomatous inflammation are?
a. particulates resisting lysosomal degradation
b. persisting molecules that stimulate T cell hypersensitivity
c. stimuli that are chemotactic for macrophages and neutrophils
d. A and B
E. all
D. A, B
granulomatous inflammation is almost always
a. acute
b. chronic
b. chronic
inflammatory cells central to granulomatous inflammation?
a. macrophages
b. epithelial cells
c. multinucleated giant cells
d. all
e. A, C
E. A, C
Do not confuse epithelial with epithelioid
If epitheliod (modified macrophages) were a choice then it would be all
which conditions favor tissue repair by fibrosis follwoing injury?
a. lack of renewable cell population
b. prolonged/severe injury
c. minimal exudate
d. A, B
e. all
D. A, B
which tissues are highly susceptible to repair by fibrosis or scarring bc they lack dividing renewable cell populations?
a. renal tubular epithelium
b. myocardial myocytes
c. cerebral cortical neurons
d. all
e. b, c
E. B, C
renal tubules do have renewing ability
ON EXAM! Which of the following are potent inducers of angiogenesis a. VEGF B. B-FGF C. HGF D. A, B E All
D. A, B (VEGF and B-FGF)
which of the following is a potent inducer of fibrosis? a. TGF beta b. TNF alpha C. PDGF D. A, B E. All
E. ALL
type 1 anaphylactic hypersensitivity reactions can be mediated by a. IgG b. IgM C. IgE D. A, B E. A, C
E. A, C (IgG and IgE)
Which of the follwoing inflammatory mediators play a central role in anaphylaxis? a. histamine b. LTC4, LTD4, LTE4 c. C5a D. A, B E. all
D. A, B
ON EXAM: type 3 hypersensitivity reactions can be mediated by: a. IgG b. IgM C. IgE D. A, B E. A, C
D. A, B
Tissue injury in type 4 hypersensitivity/allergic reactions is mediated via?
a. immune complex formation
b. t cell induction of granulomatous inflammation
c. direct t cell cytotoxicity
d. all
e. B, C
E. B, C
ON EXAM: type 3 immune complex hypersensitivity reactions occur most commonly in a state of?
A. Antigen excess
B. Antibody excess
c. antigen-antibody equivalence
A. Ag excess
