Lecture 7 - inflammation and repair

Question 1

2 mechanisms of tissue injury in inflammation

Answer 1

1. leukocyte mediated damage w/o abnormal immune response

2. immune mediated damage due to hypersensitivity/autoimmune

Question 2

__ is dz mediated by Ab or cells directed at EXTRINSIC Ag

Answer 2

allergic (hypersensitivity) dz

Question 3

__ is dz mediated by Ab or cells directed at INTRINSIC/SELF Ag

Answer 3

autoimmune dz

Question 4

__ is an example of Type 1 hypersensitivity

Answer 4

anaphylaxis and allergic dermatitis

Question 5

Type 1 hypersensitivity Mediators _ and _ bound to basophils/mast cells

Answer 5

IgE and IgG

Question 6

anaphylaxis, allergic dermatitis, drug and vaccine reactions, parasite reactions, feline asthma and COPD in horses

Answer 6

type 1 hypersensitivity (anaphylaxis type)

Question 7

type 3 hypersensitivity mediators __ and __ work via immune complexes, activation of complement and inflamm mediator release

Answer 7

IgG, IgM

Question 8

serum sickness, immune complex vasculitis and glomerulonephritis, and extrinsic allergic alveolitis

Answer 8

type 3 hypersensitivity (immune complex type)

Question 9

what immune complex in dogs leads to uveitis and corneal edema

Answer 9

infectious canine hepatitis

Question 10

4 immune complexes in dogs that lead to glonerulonephritis

Answer 10

1. pyometra
2. systemic lupus
3. chronic dirofilariasis
4. lyme (borrelia)

Question 11

what immune complexes in cats lead to glonerulonephritis

Answer 11

feline infectious peritonitis and feline leukemia

Question 12

what immune complex in horses lead to glomerulonephritis

Answer 12

equine infectious anemia and Strep. equi infeciton

Question 13

what immune complex dz in cows leads to glomerulonephritis

Answer 13

bovine virus diarrhea virus

Question 14

what immune complexes in pigs lead to glomerulonephritis

Answer 14

african swine fever and hog cholera

Question 15

immune complexes form if there is

Answer 15

excess Ag

Question 16

2 things that occur with renal failure in chronic glomerulonephritis from type 2 hypersensativity

Answer 16

1. protein losing nephropathy

2. decreased renal perfusion

Question 17

Hypersensativities by mediator “Even Girls Might Gag on Men Growing Tall”

Answer 17

Type 1 = IgE and IgG
Type 2 = IgM and IgG
Type 3 = IgM and IgG
Type 4 = T - cell

Question 18

mediators of type 4 hypersensitivity (cell mediated)

Answer 18

CD4 and CD8 T-cells

Question 19

what hypersensativity is macrophage dominated and upregulated by INF gamma

Answer 19

type 4

Question 20

3 ways cytotoxic T cells induce cell death

Answer 20

1. perforin cell membrane lysis (necrosis)
2. perforin-granzyme induced apoptosis
3. FASL-FAS induction of apoptosis