Lecture 6 - Inflammation and repair Flashcards
4 things that cause fibrosis to be favored over regeneration
- severe/prolonged injury
- loss of basement membrane
- large amounts of exudate
- lack of renewable cells (non-dividing)
most tissues have a __ cell population of cells with latent capacity to regenerate, if tissue is damaged the neighboring cells can leave G0, divide and migrate to replace
stable
__ do not enter G0 (quiescent) state/they continue to multiply throughout life, these cells have lots of repair compacity
labile
3 examples of labile cells
epithelial, hematopoietic, and lymphoid cells
5 examples of stable cells (can divide and migrate)
- epithelial cells in lung, liver, kidney, endocrine glands
- endothelial cels
- fibroblasts
- smooth m
- +/- skeletal m
non-dividing cells do not have the capacity to __ they only have limited capacity to regenerate portions of cell cytoplasm post injury. give 2 examples!
divide, cardiac myocytes and neurons
only repair for non-dividing cells of the heart and neurons is by
scarring
4 stem and progenitor cells in tissues
- skin - hair follicle bulge stim cells and interfollicular epidermal stem cells
- intestinal crypt stem cells
- liver oval cells
- eye corneal stem cells
4 things that favor regeneration over scarring
- mild/brief injury
- maintenance of basement membrane/microvascular/tissue framework
- SMALL amounts of exudate
- renewable cells (dividing progenitor/stem cells)
healing by __ there is little exudate and tissue elements are close (no large gap)
first intention
healing by __ the edges of wound are wide apart, damaged area contians exudate and necrotic debris, fills in with granulation tissue but leaves large area of fibrosis (scar)
second intention
__ is the replacement of fibrin and necrotic debris by granulation tissue
organization
__ is highly organized form of fibrovascular tissue with orderly episodes of mac influtration, stimulation of angiogenesis and fibrosis and maturation to dense c.t. scar
granulation tissue
__ in horses is an example of exuberant granulation tissue producing proliferative lesions
proud flesh
is granulomatous inflammation the same as granulation tissue
NO