Salivary Glands Flashcards
Concentrations in salvia
Lower Na, Cl, higher K and HCo3
Hypotonic and alkaline
Kallikrein
Released by slaivary
Causes breakdwon of kininogen into bradykinin…this causes local vasodilation and inc blood flow to actively secreting gland - just in time delivery
Name the glands and how they differ
Slightly acidic at rest…basic at high flow
ALWAYS hypotonic but less so at high flow rate
Partoid - serous and amylase (ptyalin)…accounts for 25% at rest but 70% during stimulation
Submandibular - both serous and mucous and majorty of rest
Sublingual - mucus and 5%
Buccal
Fxns of saliva
Lubrcation Amylase - pH 4-11 Oral hygeine Taste Breakdwon of things
Formation of secretions
Primary secretion is ultrafiltrate of plasma that is then modified in order to change concetrations
Process of formation in mroe detail
Need very high blodo flow…first to ducts and then acini
Acinar cells secrete salivary alpha amylase and lingual lipase
Duct cells modify the concentrations
Na-K exchangfe
HCO3-Cl exhcnage
Aldosterone will inc Na/K exchange
Faster flow rates lead to less complete modifcation
Duct lumen
Basolateral lumen
Cl-HCO3 exchanger
Cl channel
Na channnel
K channel
HCO3/Na uniporter
Cl channel
Na/K atpase
Concentrations and how they change with flow
K will go down as flow increases
The rest will continue to go up
Regulation of salivary glands
No classic GI homronal control but Na changed by ADH and alsodsterone
ANS - NTS and superior and inferoir salivary nuceli
PNS - 7 and 9 CN…cholinergic
SNS - inc in salivation - mostly mucous - Beta adrenergci
Cellular - inc cAMP
Dysfunction
Siallorhea - rabies
Xerostomia - dry motuh
inflammation - mumps…pain with sretching of capsule with mechanisreceptors
Pathway for salivation neural
Salivary nucleus in the medulla to
Otic - to parotid
Submandiular - to submandibular
