Pharmacology and the Liver

Question 1

Bioavailbaility

Answer 1

Drug given as a tablet/drug given as an IV injection

Question 2

Therapetuic window

Answer 2

Less than toxic drug concentration but greater than minimum

Question 3

Hepatic metabolis

Answer 3

Lipophilic drugs not eliminated by kidney so diffuse back into blood…liver metabolize and the metabolites eliminated in the urine or bile

Question 4

Biliary excretion

Answer 4

Good for large and hydrophilic drugs

If already hydrophilic, may enter as a charged drug

Others are may hydrophic by conjugated

Question 5

If elimination slows

Answer 5

Renal failure is ex

Peak conc is higher and delayed

AUC inc

Question 6

Albumin
alpha 1 acid glyco protein
Lipoproteins

Answer 6

Binds weak acids and is most abundant and important

For basic

For lipophilic

Question 7

Phases of metabolism

Answer 7

1 - oxidation

2 - attach polar molecule in conjugation

Question 8

Isonizaid

Answer 8

Neutiris and hepatotoxicyt

Question 9

Rifampin

Answer 9

Hepatotoxicity and P450 inducer

Question 10

Pyrazinamide

Answer 10

Hepatitis

Question 11

Ribavirin

Answer 11

Disrupts viral replication

Question 12

Sofosbuvier and ledipasvir

Answer 12

Sof - inhibitor of NS5B and RDRP

Led - inhibits NS5A….needed for replication

Question 13

Paritaprevir

Answer 13

NS3-4A inhibt which is a viral protease

Does NOT cure the infection