Liver Pathology

Question 1

Acinar zones

Answer 1

1 - periportal
2 - midzonall
3 - centrilobular (most likely to get ischemia)

Question 2

Necorsis in the liver

Answer 2

Acidophil bodies - apoptosis

Zonal necrosis - centriblobular is most common
Midzonal for yellow fever
Periportal for phosphorus

Question 3

Causes of centrilobular necrosis of the liver

Answer 3

Hypotension
CHF
Drug toxicity (tylenol)

Question 4

Mech of acetominophen OD

Answer 4

Acet normal excreted as glucouronate and sulfate

Alcoholics havbe more CYP2E1…convert to NAPQI…less glutathione

Question 5

Interface hepatitis

Answer 5

Hep C
Hep B 
AI hep
Primary biliary and scelorising cholangitis 
alpha 1 AT

Question 6

Cirrhosis

Answer 6

Diffuse, bridging fibrosis and regenerating nodules

Could be from alcoholic liver dz
Hep B or C (C more common)
NAFLD

Question 7

CM of cirrhosis

Answer 7

IMpaired hepatic metab of estrogen

Impaired synthesis of albumin and coagulation

Hepatorenal syndrome

Question 8

FLD etiologies

Answer 8

Alcoholic

Non alcoholic from obesit yor T2DM

See fatty liver
Steatohepatitis - alcoholic or NASH
cirrhosis

Occur sequentuially

Question 9

Drug and toxin induced liver injury

Answer 9

Indistinuishable from other etiologies

Question 10

Echinacea

Answer 10

Herbs that supposedly increase immune system

Question 11

Green tea extract

Answer 11

Smarter, burn fat, antioixdants