RNA viruses Flashcards
what kind of genetic material is in the reovirus?
DS linear RNA
is the reovirus positive or negative sense?
positive
is the reovirus segmented?
yes, 10-12 segments
is the reovirus enveloped?
no
what kind of genetic material is in a picornavirus?
ss linear RNA
is the picornavirus negative or positive sense?
positive
is the picornavirus enveloped?
no
poliovirus is a member of
picornavirus
rhinovirus is a member of
picornavirus
what kind of genetic material is in favivirus
ss linear RNA
are faviviruses enveloped?
yes
are flaviviruses positive or negative sense?
positive
faviviruses are caused by
zoonotic spread
what type of genetic material is in orthomyxovirus?
- sense ss linear RNA
where do orthomyxoviruses replicate?
nucleus
how many segments do orthomyxoviruses have?
8
are orthomyxoviruses enveloped?
yes
what kind of capsid do orthomyxoviruses have?
helical
hemagglutinin binds to
sialic acid receptors on host cell to promote viral entry
influenza is caused by
orthomyxoviruses
antigenic shift
reassortment of entire genome, shift in phenotype
antigenic shift causes
pandemics
antigenic drift
point mutations
antigenic drift causes
epidemics
neuraminidase promotes
viral progeny release
classic influenza presentation
fever, cough, sore throat, myalgia
oseltamivir, zanamivir
NA inhibitors
oseltamivir, zanamivir treat which strain of the flu
A and B
amantidine
impairs viral uncoating
amantidine is used against what flu strain
A
paramyxoviruses have what genetic material
-sense ss linear RNA
are paramyxoviruses enveloped?
yes
are paramyxoviruses segmented?
no
virulence factors: paramyxoviruses
HA
NA
matrix protein
F protein
pavlizimuab
RSV PPX in premature infants
RSV causes ____ in infants
bronchiolitis
croup is caused by
parainfluenza virus
laryngotracheobronchitis
croup
barking seal like cough and inspiratory stridor
croup
steeple sign
croup
prodromal fever with cough, coryza, conjunctivitis, koplik spots
measles
koplik spots
bright red spots with blue white center on buccal mucosa
maculopapular rash that starts at the head/neck and spreads down
measles
Warthin-Finkeldey giant cells
measles
non-specific prodrome (fever, malaise, headaches, myalgias)
mumps
parotitis, orchitis
mumps
aseptic meningitis
mumps
what genetic material is in rhabdoviruses?
- sense ss linear RNA
are rhabdoviruses enveloped?
yes
are filoviruses enveloped?
yes
what kind of capsid do filoviruses have?
helical
what kind of genetic material to filoviruses have
-sense linear ssRNA
what kind of genetic material do arenaviruses have?
+ and - sense circular ssRNA
2 segments
what kind of capsid do arenaviruses have?
helical
what kind of genetic material is in bunyaviruses?
-sense circular ssRNA
3 segments
is bunyavirus enveloped?
yes
what kind of capsule does bunyavirus have?
helical