DNA viruses

Question 1

are herpesviruses enveloped?

Answer 1

yes

Question 2

do herpesviruses have a linear or circular chromosome?

Answer 2

linear

Question 3

what kind of virus are herpesvirus?

Answer 3

dsDNA

Question 4

herpesviruses replicate using

Answer 4

DNA dependent DNA polymerase

Question 5

how to herpesviruses get their membrane?

Answer 5

budding from the nuclear membrane of host cell

Question 6

transmission: HSV1

Answer 6

contact with infected lesions

Question 7

grouped vesicles on erythematous base

Answer 7

HSV-1, HSV-2

Question 8

gingivostomatitis

Answer 8

HSV-1

Question 9

herpetic whitlow

Answer 9

HSV-1

Question 10

where does HSV1 establish dormancy?

Answer 10

trigeminal ganglia

Question 11

how do herpesviruses reactivate?

Answer 11

anterograde transport to epithelial cells

Question 12

herpes labialis, erythema multiforme, keratoconjuctivitis

Answer 12

HSV-1

Question 13

temporal lobe encephalitis

Answer 13

HSV1

Question 14

“punched out” ulcers on endoscopy

Answer 14

HSV-1

Question 15

diagnosis: HSV1/HSV-2

Answer 15

PCR/viral culture is gold standard
Tzank smear for multinucleated giant cells

Question 16

Cowdry bodies

Answer 16

HSV-1, HSV-2

Question 17

Treatment: HSV-1/HSV-2

Answer 17

acyclovir, valacyclovir

Question 18

transmission HSV2

Answer 18

sexual contact, perinatal contact

Question 19

herpes genitalis

Answer 19

HSV2

Question 20

HSV2 establishes dormancy in

Answer 20

sacral ganglia

Question 21

how do herpesviruses establish dormancy?

Answer 21

enter sensory nerve and move via retrograde transport into gangle

Question 22

viral meningitis

Answer 22

HSV2

Question 23

HHV3 aka

Answer 23

VZV

Question 24

transmission HHV3

Answer 24

respiratory droplet
direct contact with infected lesions

Question 25

VZV replicates in

Answer 25

T cells

Question 26

Chickenpox

Answer 26

vesicular rash caused by VZV (HHV3)

Question 27

primary infection of _________ in immunocompromised can cause encephalitis and pneumonia

Answer 27

VZV (HHV3)

Question 28

where does VZV establish latency?

Answer 28

dorsal root ganglia

Question 29

shingles affects a single __________

Answer 29

dermatome

Question 30

shingles is often complicated by

Answer 30

post herpetic neuralgia

Question 31

shingles causes a ____________ nerve pain

Answer 31

burning/stabbing

Question 32

Shingles nerve pain usually ___________ the rash

Answer 32

preceeds

Question 33

Ramsay-Hunt syndrome

Answer 33

otitis/facial paralysis caused by VZV

Question 34

blindess due to VZV is caused by

Answer 34

CN V1 branch involvment

Question 35

blindness due to VZV is called

Answer 35

herpes zoster ophthalmicus

Question 36

Treatment: shingles

Answer 36

famciclovir, valacyclovir analgesics to control nerve pain

Question 37

diagnosis: VZV

Answer 37

PCR is gold standard Tzank smear

Question 38

why is a Tzank smear outdated?

Answer 38

poor sensitivity/specificity

Question 39

HHV4 aka

Answer 39

EBV

Question 40

EBV is common in

Answer 40

teens, young adults

Question 41

EBV is transmitted through

Answer 41

saliva

Question 42

EBV infects B cells through

Answer 42

CD21

Question 43

EBV establishes latency in

Answer 43

B cells

Question 44

monospot positive

Answer 44

EBV

Question 45

classic mononucleosis presentation

Answer 45

pharyngitis lymphadenopathy splenomegaly

Question 46

Burkitt lymphoma

Answer 46

EBV

Question 47

nasopharyngeal carcinomas

Answer 47

EBV

Question 48

oral hair luekoplakia

Answer 48

EBV

Question 49

morbilliform rash after penicillin

Answer 49

EBV

Question 50

atypical lymphocytes

Answer 50

EBV

Question 51

transmission: CMV

Answer 51

transplants, through placenta, close contact, sexual exposure

Question 52

retinitis, colitis, linear esophagitis

Answer 52

CMV

Question 53

post transplant patient are at high risk for _____ pneumonia

Answer 53

CMV

Question 54

CMV aka

Answer 54

HHV5

Question 55

congentital CMV is associated with

Answer 55

sensorineural hearing loss

Question 56

histopath: CMV

Answer 56

owl's eyes inclusions

Question 57

negative monospot

Answer 57

CMV

Question 58

treatment: CMV

Answer 58

gancicolvir/valganciclovir

Question 59

cotton wool exudates

Answer 59

CMV retinitis

Question 60

roseola

Answer 60

HHV-6/7

Question 61

what ages does roseola affect?

Answer 61

6-24 months

Question 62

roseola is characterized by

Answer 62

high fever for 3-5 days followed by maculopapular rash that starts on the neck and spreads out to extremities

Question 63

HHV8 causes _________ in HIV patients

Answer 63

Kaposi Sarcoma

Question 64

HHV8 inhibits

Answer 64

tumor suppression pathway

Question 65

HHV-8 causes what kind of rash

Answer 65

discolored skin lesions: blue/red/violet/purple

Question 66

Poxvirus replicates in the ______

Answer 66

cytoplasm

Question 67

largest DNA virus

Answer 67

poxvirus

Question 68

is the poxvirus enveloped?

Answer 68

yes

Question 69

what kind of genetic material is in the poxvirus?

Answer 69

DS linear DNA

Question 70

is the adenovirus enveloped?

Answer 70

no

Question 71

what kind of genetic material is in the adenovirus?

Answer 71

DS linear DNA

Question 72

what kind of genetic material is in the papillomavirus?

Answer 72

DS circular DNA

Question 73

what kind of genetic material is in the polyomavirus?

Answer 73

DS circular DNA

Question 74

what kind of genetic material is in the parvovirus?

Answer 74

SS linear DNA

Question 75

what is the smallest DNA virus?

Answer 75

parvovirus

Question 76

causes a "slapped cheek" rash in children

Answer 76

parvovirus

Question 77

fifth disease

Answer 77

parvovirus

Question 78

is the adenovirus enveloped?

Answer 78

no

Question 79

what kind of genetic material is in the hepadnavirus?

Answer 79

DS circular DNA

Question 80

is the hepadnavirus enveloped?

Answer 80

yes

Question 81

hepadnaviruses use _____ to replicate

Answer 81

reverse transcriptase

Question 82

is the papillomavirus enveloped?

Answer 82

no

Question 83

is the polyoma viruse enveloped?

Answer 83

no

Question 84

is the parvovirus enveloped?

Answer 84

no