Complement

Question 1

C3 convertase

Answer 1

cleaves C3 into C3a and C3b

Question 2

C3a is an

Answer 2

anaphylatoxin (activates mast cells)

Question 3

C3b remains bound to improve

Answer 3

opsionization (stimulates phagocytosis)

Question 4

C5 convertase

Answer 4

cleaves C5 into C5a and C5b

Question 5

C5a is an _______ and promotes ______

Answer 5

anaphylatoxin; chemotaxis

Question 6

C5a activates mast cells to

Answer 6

release histamine

Question 7

C5a attracts _____ to the site of activation

Answer 7

neutrophils

Question 8

C5b

Answer 8

remains bound

Question 9

C5b combines with _______ to form the MAC

Answer 9

C6-C9

Question 10

MAC

Answer 10

membrane attack complex

forms holes in activating membrane causing cell death

Question 11

C6-C9 are known as

Answer 11

terminal complement proteins

Question 12

terminal complement protein deficiency leads to susceptibility to

Answer 12

Neisseria

Question 13

activates classical pathway

Answer 13

IgM; IgG

Question 14

C1 is activated by

Answer 14

IgG or IgM

Question 15

C1 is regulated by

Answer 15

C1 esterase inhibitor

Question 16

defective C1 esterase inhibitor causes

Answer 16

hereditary angioedema

Question 17

what class of medications is contraindicated in C1 esterase inhibitor deficiency?

Answer 17

ACE inhibitors

Question 18

activated C1

Answer 18

cleaves C4 and C2

Question 19

C4 and C2 combine to form

Answer 19

C3 convertase

Question 20

goal of classical pathway

Answer 20

kill cells with bound antibody

Question 21

goal of alternative pathway

Answer 21

kill foreign cells

Question 22

complement pathway begins with

Answer 22

spontaneous cleavage of C3 (inherently unstable)

Question 23

C3b is stabilized by

Answer 23

microbial surfaces

Question 24

Factors H and I

Answer 24

inhibit C3b preventing complement activation on normal cells

Question 25

C3b cleaves

Answer 25

Factor D and Factor B

Question 26

Factor B + C3b =

Answer 26

C3 convertase

Question 27

goal of lectin pathway

Answer 27

kill microbes expressing mannose

Question 28

MBL binds _____ on pathogen surface

Answer 28

mannose

Question 29

______ is expressed on many microbial surfaces

Answer 29

mannose

Question 30

MBL forms a complex that cleaves

Answer 30

C4 and C2 using MASPs

Question 31

Cleaved C2 + C4 combine to form

Answer 31

C3 convertase

Question 32

causes of C3 consumption

Answer 32

C1 esterase inhibitor and Factor 1 deficiencies

Question 33

cause of C4 depletion

Answer 33

C1 esterase inhibitor deficiency