Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IBI Test I > Complement > Flashcards

Complement Flashcards

1
Q

C3 convertase

A

cleaves C3 into C3a and C3b

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

C3a is an

A

anaphylatoxin (activates mast cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

C3b remains bound to improve

A

opsionization (stimulates phagocytosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

C5 convertase

A

cleaves C5 into C5a and C5b

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

C5a is an _______ and promotes ______

A

anaphylatoxin; chemotaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

C5a activates mast cells to

A

release histamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

C5a attracts _____ to the site of activation

A

neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

C5b

A

remains bound

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

C5b combines with _______ to form the MAC

A

C6-C9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MAC

A

membrane attack complex

forms holes in activating membrane causing cell death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

C6-C9 are known as

A

terminal complement proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

terminal complement protein deficiency leads to susceptibility to

A

Neisseria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

activates classical pathway

A

IgM; IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

C1 is activated by

A

IgG or IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

C1 is regulated by

A

C1 esterase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

defective C1 esterase inhibitor causes

A

hereditary angioedema

17
Q

what class of medications is contraindicated in C1 esterase inhibitor deficiency?

A

ACE inhibitors

18
Q

activated C1

A

cleaves C4 and C2

19
Q

C4 and C2 combine to form

A

C3 convertase

20
Q

goal of classical pathway

A

kill cells with bound antibody

21
Q

goal of alternative pathway

A

kill foreign cells

22
Q

complement pathway begins with

A

spontaneous cleavage of C3 (inherently unstable)

23
Q

C3b is stabilized by

A

microbial surfaces

24
Q

Factors H and I

A

inhibit C3b preventing complement activation on normal cells

25
Q

C3b cleaves

A

Factor D and Factor B

26
Q

Factor B + C3b =

A

C3 convertase

27
Q

goal of lectin pathway

A

kill microbes expressing mannose

28
Q

MBL binds _____ on pathogen surface

A

mannose

29
Q

______ is expressed on many microbial surfaces

A

mannose

30
Q

MBL forms a complex that cleaves

A

C4 and C2 using MASPs

31
Q

Cleaved C2 + C4 combine to form

A

C3 convertase

32
Q

causes of C3 consumption

A

C1 esterase inhibitor and Factor 1 deficiencies

33
Q

cause of C4 depletion

A

C1 esterase inhibitor deficiency

IBI Test I (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions