DIC Flashcards
1
Q
Pathogenesis of DIC:
A
release of procoagulants -> widespread abnormal clotting -> consumption of platelets and clotting factors -> susceptibility to bleeding
2
Q
microangiopathic hemolysis
A
microthrombi formation causes mechanical shearing of RBCs
3
Q
DIC presentation
A
bleeding from all orifices
dermal purpura
multi organ failure
shock
4
Q
DIC: decreased platelet count, increased bleeding time
A
due to consumption of platelets in microthrombi
5
Q
increased PT and PTT, decreased fibrogen
A
due to consumptive use of clotting factors
6
Q
DIC associated pathology:
A
shistocytes
nutmeg liver
shock liver
dermal purpura
7
Q
Treatment DIC:
A
supportive fluids, blood products, pressors
treat underlying disorder
