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IBI Test I > Biologics > Flashcards

Biologics Flashcards

1
Q

conventional DMARDS

A

methorexate
leflunomide
hydroxychloroquine
sulfasalazine
azathioprine

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2
Q

first line RA treatment

A

methotrexate

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3
Q

inhibition of dihydrofolate

A

methotrexate

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4
Q

give folic acid with

A

methotrexate

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5
Q

mechanism: methotrexate

A

increases adenosine release from cell walls

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6
Q

administration: methotrexate

A

oral or subcutaneous weekly does

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7
Q

adverse effects: methotrexate

A

oral ulcers, GI, cytopenia, liver toxicity, teratogen

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8
Q

inhibition of dihydroorotate dehydrogenase

A

leflunomide

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9
Q

prodrug, enterohepatocyte circulation gives longer half life

A

leflunomide

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10
Q

administation: leflunomide

A

oral

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11
Q

adverse effects: leflunomide

A

diarrhea, cytopenias, hepatotoxicity, teratogen

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12
Q

inhibits TLRs
inhibits acidification of lysosomes

A

hydroxychloroquine

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13
Q

administration: hydroxychloroquine

A

oral

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14
Q

adverse effects: hydroxychloroquine

A

rare retinal toxicity

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15
Q

sulfapyridine is active moiety

A

sulfasalazine

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16
Q

administration: sulfasalazine

A

oral

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17
Q

adverse effects: sulfasalazine

A

rash, GI upset, hepatotoxicity, cytopenias

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18
Q

purine synthesis inhibitor

A

azathioprine

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19
Q

administration: azathioprine

A

oral

20
Q

adverse effects: azathioprine

A

cytopenias, rash GI upset, pancreatitis

21
Q

TNF inhibitors

A

biologics

reduce joint inflammation and damage to joints

22
Q

administration: etanercept

A

subcutaneous

23
Q

mechanism: etanercept

A

binds TNF and blocks its interaction with cell surface receptors

24
Q

administration: adalimumab

A

subcutaneous

25
Q

mechanism: adalimumab

A

human monoclonal antibody directed to TNF

26
Q

administration: certolizumab

A

subcutaneous

27
Q

mechanism: certolizumab

A

Fab fragment of humanized monoclonal antibody directed at TNF

28
Q

mechanism: golimumab

A

human monoclonal antibody directed to TNF

29
Q

administration: golimumab

A

subcutaneous

30
Q

mechanism: infliximab

A

chimeric monoclonal antibody against TNF

31
Q

administration: remicade

A

infusion

32
Q

humanized monoclonal antibody targeting IL-6

A

tocilizumab

33
Q

administration: tocilizumab

A

subq or IV

34
Q

antagonist of IL-1 receptor

A

anakinra

**not terribly effective against RA

35
Q

binds CD80/86 on APCs blocking the interaction of CD28

A

abatacept

36
Q

t cells cannot be activated

A

abatacept

37
Q

administration: abatacept

A

subq or IV

38
Q

monoclonal antibody directed against CD20

A

rituximab

39
Q

result is depletion of B cells, but not plasma cells

A

rituximab

40
Q

administration: rituximab

A

IV

41
Q

Tofacitinib, Baricitinib, Upadacitinib mechanism

A

JAK inhib

42
Q

administration: Tofacitinib, Baricitinib, Upadacitinib

A

oral

43
Q

treat to target

A

utilize disease activity scores to adjust therapy

44
Q

triple therapy

A

methotrexate, sulfasalazine, hydroxychloroquine

45
Q

methotrexate
leflunomide
tocilizumab
sarilumab
abatacept
rituximab
Jak inhibs

A

all teratogens

46
Q

cheaper

A

DMARDS

methotrexate
leflunomide
hydroxychloroquine
sulfasalazine

IBI Test I (18 decks)

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