Antivirals Flashcards
Anti-Influenza drugs
Oseltamivir, Zanamivir, Rimantadine
mechanism: oseltamivir, zanamivir
inhibit neuraminidase; inhibit viral progeny release
sialic acid analogs
oseltamivir, zanamivir
adverse effects: oseltamivir, zanamivir
GI upset
**zanamivir may exacerbate COPD/asthma
flu strain treated by oseltamivir and zanamivir
A and B
inhibitors of viral genome replication: HSV and VZV
acyclovir, valacyclovir
inhibitors of viral genome replication: CMV
ganciclovir, valganciclovir
Inhibitors of viral genome replication: HSV, VZV, CMV
cidofovir, foscarnet
Antihepatitis Virus
ribavirin
INF a
hepatitis B
lamivudine
tenofovir
adefovir
entecavir
telbivudine
hepatitis C
simeprevir
sofosbuvir
ledepasvir
daclatasvir
dasabuvir
Does acyclovir cure HSV/VZV infections?
no, mangement
mechanism: acyclovir, valacyclovir
nucleoside analog
guanine attached to acyclic moiety
acyclovir is activated by
thymidine kinase
ACV monophosphate is converted to
ACV triphosphate
resistance to acyclovir
mutation/loss of thymidine kinase
mechanism: ribavirin
inhibits guanine synthesis, mutates viral DNA
ribavirin is activated by
host kinases
ribavirin inhibits
RNA polymerase
Clinical Use: Ribavirin
Hep C, RSV (aerosol)
adverse effects: ribavirin
hemolytic anemia
teratogen
pruritis
resistance: ribavirin
genotype 1 HCV
administration: ribavirin
oral, inhalation
excretion: ribavirin
urine
adverse effects: acyclovir
crystalline nephropathy
renal failure with poor hydration
administration: acyclovir
oral, IV, topical
excretion: acyclovir
urine
prodrugs have higher
oral bioavailability
mechanism: ganciclovir
guanosine analog
initial phosphorylation of ganciclovir is done by
UL97
clinical use: ganciclovir
CMV first line
adverse effects: ganciclovir
bone marrow suppression
nephrotoxicity
CNS toxicity
teratogen
resistance: ganciclovir
mutated tyrosine kinase