Immunoglobulins Flashcards
Which immunoglobulin is released into secretions?
IgA
IgA is secreted as a _______ connected by a J chain
dimer
_____ provides immunity at mucus membranes
IgA
_______ protects against giardia
IgA
_______ is produced in the GI tract at Peyer’s patches and airways
IgA
Selective IgA deficiency causes recurrent….
GI and sinopulmonary infections
_____ is the most abundant antibody in serum
IgG
The slower production of _____ relative to IgM is due to the need for B cell class switching
IgG
______ crosses the placenta
IgG
______ fixes classical complement
IgG and IgM
____ and ____ bind to C1 to being classical complement activation
IgG and IgM
Opsonizes material for phagocytosis
IgG
FcR region on phagocytes recognize ________ of IgG
Fc region
______ neutralizes bacterial toxins and viruses
IgG
Default antibody produced without class switching
IgM
Defects in class switching lead to
Hyper IgM syndrome
Produced immediately in response to a new antigen
IgM
circulates as a pentamer
IgM
can IgM cross the placenta?
No, too large
binds to antigens on parasites and allergens
IgE
mediates defense against parasites
IgE
mediates allergic reactions/anaphylaxis
IgE
mediates Type I HSR
IgE
FcR of bound IgE is recognized by
mast cells and basophils
IgE crosslinking to releases ______
histamine
lowest concentration in serum
IgE
When the Fc regions of IgE is bound by eosinophils, what is released?
major basic protein
unclear function
IgD
