-RNA enveloped (Hanta, Lassa, Rabies, Ebola) Flashcards
what virus are found in the bunya family?
La Cross
California encephalitis
Hanta virus
what viruses are found in the Arena virus family?
Lassa
LCMV
what viruses are found in the Rhabdo virus family?
rabies
what viruses are found in the filo family of viruses?
Ebola
what is the transmission of La Cross and California Encephalitis?
from squirrel to mosquito which will pass it to humans
what is the transmission of Hantavirus?
aerosolized mice urine
what is the transmission of Lassa virus?
through mice urine
what is the transmission of LCMV?
through mice urine
what is the transmission of rabies?
through saliva of mammals
what is the transmission of ebola?
humans and primates transmit it
among humans, infection occurs by body fluids
what is the clinical presentation of La Cross encephalitis?
fever, headache, vomiting, meningitis
what is the clinical presentation of california encephalitis virus?
fever, headache, vomiting, encephalitis
what is the clinical presentation of Hantavirus?
Hanta Pulmonary Syndrome:
- flu-like symptoms
- pulmonary edema
- respiratory failure
Hemorrhagic Fever with renal syndrome (kidney necrosis, external bleeding)
where is Lassa virus found?
West Africa
what is the clinical presentation for Lassa virus?
Lassa fever (high fever, bleeding gyms and blood vomiting, liver/spleen necrosis)
LCMV (lymphocytic choriomeningitis virus) will infect what mice?
house mice
what is the clinical presentation of LCMV?
fever, flu-like myalgia
what is the biology of the rabies virus?
eveloped BULLET SHAPED helical single stranded -RNA
to what receptor will the VAP of rabies virus attach to?
nicotinic ACh receptor
What animal is most prone to infect with rabies?
raccoons and skunks
what happens with rabies once someone is infected?
virus can travel to CNS and to salivary glands
what is the clinical presentation of rabies during incubation?
flu-like symptoms
what is the clinical presentation of rabies after incubation?
neurological phase:
- itching at site of bite
- cerebral dysfunction
- deliruim
- hydrophobia
what is the prognosis of rabies once clinical signs appear?
disease is fatal
what diagnosis tool can be used to confirm rabies?
what cytoplasmic inclusions can be found?
antibodies in the CSF
Negri bodies
what cytoplasmic inclusion is this?
negri body
what cytoplasmic inclusion is this?
negri bodies
what rabies vaccine is given before exposure to rabies virus?
killed vaccine
what rabies vaccine is given after exposure to rabies virus?
what happens if you acquire the virus, when do you give the vaccine?
killed vaccine
human rabies immune globulin
when you acquire the virus, you must administer both vaccines before onset of symptoms
what is the clinical presentation of ebola?
extensive hemorrhage from GI and hypovolemic shock
and vomiting
