DNA Enveloped Viruses (Poxviridae)

Question 1

what is the biology of small pox?

Answer 1

enveloped complex linear dsDNA

Question 2

what is the biology of monkey pox?

Answer 2

enveloped complex dsDNA

Question 3

where does small pox replicate?

Answer 3

in the cytoplasm

Question 4

what cells are primarily targeted by small pox?

Answer 4

respiratory mucosa

Question 5

what is the course of the smallpox disease?

Answer 5

1) virus infects and multiples in respiratory mucosa cells
2) its carried to lymph nodes
3) primary viremia (carried in the blood)
4) virus reaches organs and causes skin rash
5) 2ry viremia occrus
6) dermal invasion occurs (characteristic vesicular rashes)
7) sepsis occurs

Question 6

what is essential to get rid of smallpox?

Answer 6

cell mediated immunity and humoral immunity

Question 7

why does a rash occur in smallpox?

Answer 7

because of viral replication followed by CTL attacking infected cells

Question 8

how does the rash in small pox progress? (where does the rash start and where does it move to?)

Answer 8

it starts from the mouth and spreads to face, arms, legs, hands and feet.

Question 9

how does the rash in smallpox differ from the rash in varicella?

Answer 9

the smallpox rash is asynchronous (papules will not be clustered)

Question 10

is monkey pox more severe or milder than smallpox?

Answer 10

milder

Question 11

pox virus (small and monkey) will have what type of inclusion bodies and in what part of the cell?

Answer 11

cytoplasm guarnieri inclusion bodies

Question 12

what is this?

Answer 12

guarnieri bodies

Question 13

what is vaccinia?

Answer 13

live attenuated virus vaccine

Question 14

what is variolation?

Answer 14

vaccine that causes a wound

Question 15

is there a vaccine for small pox?

Answer 15

yes

Question 16

what 4 characteristics has helped eradicate smallpox?

Answer 16

1) humans are its only host
2) there is only 1 serotype
3) once you have immunity it will be lifelong
4) it is a transient infection
5) the vaccine is inexpensive

Question 17

smallpox vaccine is with what virus?

Answer 17

vaccinia, small pox cousin

Question 18

what is the biology of molluscum contagiosum?

Answer 18

enveloped complex DNA virus

Question 19

how does molluscum contagiosum spread?

Answer 19

it is contagious by close contact and fomites

Question 20

who is most prone to get molluscum contagiosum?

Answer 20

children

Question 21

how harmful is molluscum contagiosum?

Answer 21

not harmful, benign

Question 22

what is the clinical presentation of molluscum contagiosum?

Answer 22

Raised nodular to wart-like tumors on the skin, clustered from 5-20, have a central caseous plug

Question 23

what causes this?

Answer 23

molluscum contagiosum

Question 24

what causes this?

Answer 24

molluscum contagiosum

Question 25

how do you confirm a diagnosis of molluscum contagiosum?

Answer 25

you will see molluscum bodies histologically in the cytoplasm

Question 26

what is this?

Answer 26

molluscum bodies