DNA Enveloped Viruses (Poxviridae) Flashcards
what is the biology of small pox?
enveloped complex linear dsDNA
what is the biology of monkey pox?
enveloped complex dsDNA
where does small pox replicate?
in the cytoplasm
what cells are primarily targeted by small pox?
respiratory mucosa
what is the course of the smallpox disease?
1) virus infects and multiples in respiratory mucosa cells
2) its carried to lymph nodes
3) primary viremia (carried in the blood)
4) virus reaches organs and causes skin rash
5) 2ry viremia occrus
6) dermal invasion occurs (characteristic vesicular rashes)
7) sepsis occurs
what is essential to get rid of smallpox?
cell mediated immunity and humoral immunity
why does a rash occur in smallpox?
because of viral replication followed by CTL attacking infected cells
how does the rash in small pox progress? (where does the rash start and where does it move to?)
it starts from the mouth and spreads to face, arms, legs, hands and feet.
how does the rash in smallpox differ from the rash in varicella?
the smallpox rash is asynchronous (papules will not be clustered)
is monkey pox more severe or milder than smallpox?
milder
pox virus (small and monkey) will have what type of inclusion bodies and in what part of the cell?
cytoplasm guarnieri inclusion bodies
what is this?
guarnieri bodies
what is vaccinia?
live attenuated virus vaccine
what is variolation?
vaccine that causes a wound
is there a vaccine for small pox?
yes
what 4 characteristics has helped eradicate smallpox?
1) humans are its only host
2) there is only 1 serotype
3) once you have immunity it will be lifelong
4) it is a transient infection
5) the vaccine is inexpensive
smallpox vaccine is with what virus?
vaccinia, small pox cousin
what is the biology of molluscum contagiosum?
enveloped complex DNA virus
how does molluscum contagiosum spread?
it is contagious by close contact and fomites
who is most prone to get molluscum contagiosum?
children
how harmful is molluscum contagiosum?
not harmful, benign
what is the clinical presentation of molluscum contagiosum?
Raised nodular to wart-like tumors on the skin, clustered from 5-20, have a central caseous plug
what causes this?
molluscum contagiosum
what causes this?
molluscum contagiosum
how do you confirm a diagnosis of molluscum contagiosum?
you will see molluscum bodies histologically in the cytoplasm
what is this?
molluscum bodies
