risk of cardio disease

Question 1

what are the steps of atherosclerotic plaques?

Answer 1

• endothleial damage
• protective respone results in production of callular adhesion molecules
• monocytes and T lymphocytes attach to sticky surfaces of endothelial cells
• migrate through arterial wall to subendothelial space
• macrophages take up oxidised LDL-C
• lipid-rich foam cells
• fatty streak and plaque

Question 2

what is LDL cholesterol?

Answer 2

• associated with atheroscleosis and CHD events

- 10% increase results in a 20% increase in CHD risk

Question 3

what are triglycerides?

Answer 3

• increased risk of CHD events
• normal triglyceride levels 2.3mmol/l
• very high triglycerides 11.3mmol/l increased pancretitis risk