origin and conduction of cardiac impulse Flashcards

1
Q

where in the heart does excitation originate?

A
  • in the pacemaker cells in the SA node (a cluster of specialised pacemaker cells)
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2
Q

where is the SA node located?

A

upper right atrium (close to where the SVC enters the right atrium)

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3
Q

what does sinus rhythm mean?

A

when the heart is controlled by the SA node

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4
Q

how does cardiac excitation originate?

A
  • the cells in the SA node have no stable resting membrane potential and generate spontaneous pacemaker potentials
  • the spontaneous pacemaker potential takes the membrane potential to a threshold and an action potential is generated, resulting in the generation of regular spontaneous action potentials in the SA nodal cells
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5
Q

what is the pacemaker potential due to?

A
  • a decrease in K+ efflux
  • Na+ and K+ influx
  • transient Ca++ influx

(pacemaker potential is the upward stroke at the bottom)

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6
Q

what happens once the threshold is reaches?

A
  • the rising phase of action potential (depolarisation) is caused by activation of L-type Ca++ channels which results in Ca++ influx
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7
Q

what causes the falling phase of action potential? (repolarisation)

A
  • inactivation of L-type Ca++ channels and activation of K+ channels which result in K+ efflux
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8
Q

what is the AV node, where is it located and what does it do?

A
  • bundle of specialised cardiac cells
  • located at the base of the right atrium, above junction of arita and ventricles
  • AV node is the only point of electrical contact between atria and ventricles
  • AV node cells are small in diameter and have slow conduction velocity
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9
Q

how does cardiac excitation spread?

A
  • across the atria (cells to cell conduction via gap junctions)
  • from SA node to AV node (cells to cell via gap junctions but also some internodal pathways)
  • the conduction is delayed in the AV node (this allows artial systole to precede ventricular systole = contraction)
  • the bundle of his and its branches and the network of purkinje fibres allows rapid spread of action potential to the ventricles
  • ventricular muscle (cells to cell)
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10
Q

what happens in phase 0 of action potential in contractile cardiac muscle cells?

A
  • the resting membrane = -90mV
  • rising phase of action potential (depolarisation) is caused by fast Na+ influx
  • membrane potenetial is then +20mV
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11
Q

what are the phases of ventricular muscle action potential?

A

0 = fast Na+ influx
1 = closure of Na+ channels and transient K+ efflux
2 = mainly Ca++ influx
3 (falling phase)= closure of Ca++ channels and K+ efflulx
4 = resting membrane potential

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12
Q

what is the plateau phase?

A
  • the membrane potential is . maintained near the peak of action potential for a few hundred milliseconds
  • it is a unique characteristic of contractile cardiac muscle cells
  • the plateau phase is mainly due to influx of Ca++ through L-type Ca++ channels
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13
Q

what is the falling phase of ventricular muscles action potential?

A
  • (repolarisation)
  • caused by inactivation of Ca++ channels and activation of K+ channels
  • resulting in K+ efflux
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14
Q

what changes the heart rate?

A
  • HR is mainly influenced by the autonomic nervous system
  • sympathetic stimulation increases the heart rate
  • parasympathetic stimulation decreases the heart rate
  • changes in HR involve a reciprocal action of sympathetics and parasympathetics
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15
Q

how does the autonomic nervous system influence the normal HR?

A
  • the vagus nerve (para) exerts a continuous influence on the SA node under resting conditions
  • vagal tone dominates under normal resting conditions
  • vagal tone slows the intrinsic HR from 100bpm to 70bmp
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16
Q

what is normal resting HR?

A

between 60 and 100 bpm

17
Q

what is bradycardia?

A

resting HR under 60bpm

18
Q

what is tachycardia?

A

resting HR over 100bpm

19
Q

how does parasympathetic influence the heart?

A
  • vagus nerve supplies SA node and AV node

- vagal stimulation slows heart rate and increase aV nodal delay

20
Q

how does sympathetic influence the heart?

A
  • cardiac sympa nerve supply the SA node and AV node and myocardium
  • sympa stimulation increases HR and decreases AV nodal delay
  • also increases the force of contraction
21
Q

what is the neurotransmitter for parasympathetic?

A
  • neurotransmitter is acetyle choline acting through M2

- atropine is a competitive inhibitor of acetylcholine - used in extreme bradycardia to speed up the heart rate

22
Q

what is the neurotransmitter for sympathetic?

A

neurotransmitter is noradrenaline acting through B1 adenoceptors.

23
Q

what are the standard leads?

A
1 = RA - LA
2 = RA - LL
3 = LA - LL
24
Q

what are the ECG records?

A
P = atrial depolarisation (first small bump)
ORS = ventricular depolarisaiton (spike)
T = ventricular repolarisation (seond large bump)
PR = largery AV node delay (line after spike)
ST = segment ventricular systole (line after spike)
TP = diastole (long line)