Rheumatoid Arthritis-DMARDS and biologics

Question 1

hydroxychloroquine (HCQ) MOA

Answer 1

increases intracellular pH of cytoplasmic vesicles; proposed to interfere with ag processing in APCs leading to decreased formation of peptide-MHC protein complexes, leading to decreased immune response

Question 2

hydroxychloroquine treats

Answer 2

RA and malaria

Question 3

hydroxychloroquine side effects

Answer 3

n/d, retinopathy and cardiomyopathy, don’t use in G6PD deficient pts

Question 4

sulfasalazine (SSZ) MOA

Answer 4

not fully understood, reduced in the colon by bacterial enzymes, may reduce cytokine release, may inhibit NFkB

Question 5

sulfasalazine treats

Answer 5

RA

Question 6

sulfasalazine side effects

Answer 6

n/v, anemia, hemolytic anemia in G6PD deficiency

Question 7

what are all the DMARD drugs

Answer 7

HCQ, SSZ and MTX

Question 8

Adalimumab MOA

Answer 8

mab that binds to TNFalpha

Question 9

adalimumab treats

Answer 9

RA

Question 10

adalimumab side effects

Answer 10

risk of infections

Question 11

etanercept MOA

Answer 11

TNF alpha decoy receptor, fused to Fc region of IgG

Question 12

etanercept treats

Answer 12

RA

Question 13

etanercept often combined with

Answer 13

MTX

Question 14

Tocilizumab MOA

Answer 14

mab that binds to IL-6 receptor and blocks IL-6 binding

Question 15

tocilizumab treats

Answer 15

RA

Question 16

Anakinra MOA

Answer 16

recombinant IL-1 receptor antagonist

Question 17

anakinra treats and side effects

Answer 17

RA and risk of infections

Question 18

Tofacitinib MOA

Answer 18

inhibitor of JAK/STAT

Question 19

Tofacitinib treats and side effects

Answer 19

RA and risk of infections