Anticoagulants, Antiplatelet, Thrombolytics, Hematopoietic drugs

Question 1

heparin MOA

Answer 1

antithrombin III dependent inhibition of; thrombin (IIa) and Factor Xa

Question 2

heparin treats

Answer 2

acute/hospital setting: initial treatment for DVT, PE, MI and unstable angina

Question 3

heparin side effects

Answer 3

bleeding, heparin-induced thrombocytopenia (HIT), osteoporosis

Question 4

heparin unique properties

Answer 4

antidote: protamine sulfate, monitor by aPTT, IV infusion, safe for pregnancy

Question 5

Enoxaparin MOA

Answer 5

Antithrombin III dependent inhibition of : factor Xa

Question 6

enoxaparin treats

Answer 6

DVT, PE, MI

Question 7

enoxaprin side effects

Answer 7

Bleeding, HIT

Question 8

enoxaprin unique properties

Answer 8

antidote: protamine sulfate, IV infusion, safe for pregnancy

Question 9

Warfarin MOA

Answer 9

orally active inhibition of vit K epoxide reductase, depletes liver production of Vit K dependent clotting factors

Question 10

Warfarin treats

Answer 10

DVT, PE, prophylaxis in high risk pts

Question 11

warfarin side effects

Answer 11

bleeding, warfarin induced skin necrosis

Question 12

warfarin drug reactions

Answer 12

interactions with numerous RX and OTC drugs, CYP2C9 and VKOR gene variants

Question 13

warfarin unique properties

Answer 13

oral anticoagulant, monitor by PT/INR

Question 14

warfarin reversal agents

Answer 14

Vit K, Fresh frozen plasma

Question 15

Dabigatran MOA

Answer 15

orally active small molecule, direct thrombin inhibitor (DTI)

Question 16

dabigatran treats

Answer 16

Post DVT or PE, prophylaxis of DVT and PE, Prophylaxis of stroke in non-valvular Afib

Question 17

dabigatran side effects

Answer 17

gi bleeding, renal insuffiency pts,

Question 18

dabigatran drug reactions

Answer 18

azole antifungals

Question 19

dabigatran unique properties

Answer 19

novel oral anticoagulant, no monitoring

Question 20

dabigatran antidote

Answer 20

Idarucimab

Question 21

Rivaroxaban MOA

Answer 21

orally active small molecule, factor Xa inhibitor

Question 22

Rivaroxaban treats

Answer 22

Prophylaxis of DVT and PE in pts with hip or knee replacement

Question 23

rivaroxaban side effects

Answer 23

minor bleeding

Question 24

rivaroxaban unique properties

Answer 24

no monitoring or antidote

Question 25

Aspirin treats

Answer 25

prophylaxis of stroke and MI

Question 26

Aspirin drug interactions

Answer 26

heparin and warfarin

Question 27

Abciximab MOA

Answer 27

monoclonal Fab targetting GPIIb/IIIa

Question 28

Abciximab treats

Answer 28

during angioplasty

Question 29

Clopidogrel MOA

Answer 29

inhibition of platelet P2Y12 ADP receptors, irreversible inhibitor

Question 30

clopidogrel treats

Answer 30

used with aspirin prophylaxis of thrombosis

Question 31

clopidogrel side effects

Answer 31

thrombotic thrombocytopenia purpura (TTP)

Question 32

clopidogrel unique properties

Answer 32

prodrug, must be metabolized by CYP2C19

Question 33

Alteplase MOA

Answer 33

recombinant t-PA, converts plasminogen to plasmin which degrades fibrin

Question 34

Alteplase treats

Answer 34

severe PE, MI and ischemic stroke

Question 35

Alteplase side effects

Answer 35

bleeding

Question 36

Erythropoietin MOA

Answer 36

increases RBC production by stimulating erythrocyte precursors

Question 37

Erythropoietin treats

Answer 37

anemia

Question 38

Thrombopoietin MOA

Answer 38

increases platelet production by stimulating megakaryocyte precursors

Question 39

thrombopoietin treats

Answer 39

thrombocytopenia