Chemotherapeutics: Kinase Inhibitors and Monoclonal Antibodies

Question 1

-tinib suffix for

Answer 1

tyrosine kinase inhibitors

Question 2

Gefitinib MOA

Answer 2

inhibits tyrosine kinase domain of EGFR

Question 3

Gefitinib treats

Answer 3

NSCLC

Question 4

gefitnib side effects

Answer 4

skin rash;acne syndome, diarrhea, anorexia

Question 5

gefitinib cautions

Answer 5

metabolized by CYP3A4

Question 6

CYP3A4 inhibited by

Answer 6

grapefruit juice and warfarin

Question 7

gefitinib unique properties

Answer 7

monotherapy and related drug erlotinib

Question 8

imatinib MOA

Answer 8

inhibits BCR-Abl kinase (tyrosine kinase)

Question 9

imatinib treats

Answer 9

CML and GI stormal tumors (GIST)

Question 10

imatinib side effects

Answer 10

fluid retention/CHF, n/v/d, prolong QT interval, hepatotoxicity, liver metabolism

Question 11

lapatinib MOA

Answer 11

blocks tyrosine kinase actives of EGFR and HER2/neu

Question 12

lapatinib treats

Answer 12

breast cancer

Question 13

lapatinib side effects

Answer 13

n/d, rash, can prolong QT interval, dehydration

Question 14

sunitinib MOA

Answer 14

inhibits VEGFRalpha, beta, 1,2,3 and c-kit

Question 15

sunitinib treats

Answer 15

kidney and pancreatic cancer

Question 16

sunitinib side effects

Answer 16

diarrhea, HTN, bleeding complications, CYP3A4

Question 17

sorafenib MOA

Answer 17

inhibits VEGFR2,3, PDGFR and Raf kinases

Question 18

sorafenib treats

Answer 18

kidney and liver cancers

Question 19

sorafenib side effects

Answer 19

rash & skin problems/hand-foot syndrom, HTN, bleeding complications, CYP3A4

Question 20

-xi

Answer 20

chimeric

Question 21

-mab

Answer 21

monoclonal antibody

Question 22

all Mabs can cause what kind of reaction

Answer 22

infusion reaction

Question 23

Bevacizumab MOA

Answer 23

binds and blocks VEGF-A; prevents new angiogenesis

Question 24

Bevacizumab treats

Answer 24

metastatic colorectal cancer

Question 25

bevacizumab side effects

Answer 25

HTN, Arterial thombotic events, diarrhea, stomatitis, GI perforations

Question 26

Cetuximab MOA

Answer 26

binds and inhibits EGFR signaling

Question 27

cetuximab treats

Answer 27

colorectal cancer

Question 28

cetuximab side effects

Answer 28

dyspnea, hypotension, interstitial lung dz, rash

Question 29

cetuximab rash indicative of

Answer 29

positive response to therapy

Question 30

rituximab MOA

Answer 30

antiCD20 mab, depletes B lymphocytes (attached by CD8)

Question 31

rituximab treats

Answer 31

leukemias/lymphomas (NHL and CLL)

Question 32

rituximab side effects

Answer 32

infusion reactions (some fatal), HTN, Brochospasm, angioedema, arrythimias, tumorlysis syndome can lead to kidney failure

Question 33

trastuzumab MOA

Answer 33

Blnds/blocks HER2

Question 34

trastuzumab treats

Answer 34

metastatic breast cancer

Question 35

trastuzumab side effects

Answer 35

CHF, cardiomyopathy, flu-like symptoms, n/v

Question 36

Denosumab MOA

Answer 36

targets RANK Ligand in osteoclasts, blocks bone resorption, prevents fractures

Question 37

denosumab treats

Answer 37

prostate and breast cancers

Question 38

denosumab side effects

Answer 38

osteonecrosis of the jaw and dermatological reactions

Question 39

denosumab needs to be taken with

Answer 39

calcium and vit D

Question 40

Pembrolizumab MOA

Answer 40

blocks PD1 (checkpoint inhibitor)