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Block 8 drugs > Chemotherapeutics: Hormonal Agents and miscellaneous compounds > Flashcards

Chemotherapeutics: Hormonal Agents and miscellaneous compounds Flashcards

1
Q

Aromatase inhibitors MOA

A

aromatase responsible for extra adrenal synthesis of estrogen; inhibition results in decreased estrogen production

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2
Q

aromatase inhibitors side effects

A

nausea, fatigue and hot flashes

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3
Q

aromatase inhibitor drugs

A

Aminoglutethimide, Anastrozole, Exemestane, Letrozole

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4
Q

Aminogluethimide treats

A

breast cancer

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5
Q

aromatase inhibitor drugs unique properteis

A

side effects less severe than tamoxifen

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6
Q

Anastrozole additional MOA

A

imidazole inhibitor

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7
Q

Anastrozole treats

A

breast cancer

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8
Q

Exemestane additional MOA

A

steroidal, irreversible inhibtor

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9
Q

exemestane treats

A

breast cancer

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10
Q

letrozole treats

A

breast cancer in post menopause

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11
Q

letrozole additional MOA

A

imidazole inhibitor

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12
Q

Non steroidal antiandrogens

A

Bicalutamide, Flutamide, Nilutamide

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13
Q

Non steroidal anti-androgens MOA

A

competitive antagonist to androgen receptor

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14
Q

Non steroidal anti-androgens treats

A

prostate cancer

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15
Q

Non steroidal anti-androgens side effects

A

Gynecomastia, n/v/d, visual problems, hepatotoxicity

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16
Q

Goserelin MOA

A

desensitize GnRH receptor and inhibit release of FSH and LH; decrease androgen and estrogen release

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17
Q

goserelin treats

A

prostate cancer and breast cancer post menopause

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18
Q

goserelin side effects

A

impotence, hot flashes, tumor flare

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19
Q

Leuprolide (Lupron) MOA

A

desensitize GnRH receptor and inhibit release of FSH and LH; decrease androgen and estrogen release

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20
Q

Leuprolide (Lupron) treats

A

prostate cancer and breast cancer post menopause

21
Q

Leuprolide (Lupron) side effects

A

impotence, hot flashes, tumor flare

22
Q

Prednisone treats

A

leukemia/lymphomas

23
Q

prednisone side effects

A

immunosuppression, ulcers, hyperglycemia, osteoporosis, glaucoma and cataracts

24
Q

Tamoxifen MOA

A

partial agonist inhibitor of the estrogen receptor; blocks nuclear translocation of estrogen receptor and lowers estrogen responsive genes

25
Q

Tamoxifen treats

A

high risk recurrent breast cancer

26
Q

tamoxifen side effects

A

hot flashes, n/v, menstrual complications, hypercalcemia, thromboembolism, vision complications

27
Q

Toremifene MOA

A

partial agonist inhibitor of the estrogen receptor; blocks nuclear translocation of estrogen receptor and lowers estrogen responsive genes

28
Q

Toremifene treats

A

breast cancer

29
Q

Toremifene side effects

A

hot flashes, n/v, menstrual complications, hypercalcemia, thromboembolism, vision complications

30
Q

Megestrol acetate MOA

A

synthethic progestin; progesterone receptor agonist; MOA not fully understood

31
Q

megestrol acetate treats

A

breast cancer and endometrial cancer

32
Q

Asparaginase MOA

A

hydrolyzes circulating L-arginine to aspartic acid+ammonia

33
Q

asparaginase treats

A

childhood leukemia specifically ALL

34
Q

asparaginase side effects

A

hypersensitivity reaction (fever/chills), n/v, skin rash(uticaria), ammonia toxicity

35
Q

interferon MOA

A

exact MOA unknown, finding IFN receptors results in suppression of cell proliferation

36
Q

interferon treats

A

leukemias and kaposi sarcoma

37
Q

interferon side effects

A

flu like symptoms that can be severe

38
Q

procarbazine MOA

A

oxidized/metabolized into a form that binds DNA and inhibits DNA, RNA and protein synth

39
Q

procarbazine treats

40
Q

procarbazine side effects

A

myelosuppression, n/v/d, neurotoxicity, mutagen, teratogen,

41
Q

procarbazine unique properties

A

inhibits monoamine oxidase; food drug interactions leading to HTN crisis

42
Q

Arsenic trioxide MOA

A

believed to induce apoptosis in cancer cells by release of cyt C from mito and caspase activation

43
Q

arsenic trioxide treats

A

drug resistant AML

44
Q

arsensic trioxide side effects

A

fatigue, prolonged QT, heavy metal toxicity

45
Q

arsensic trioxide is used in combo with

A

all-trans retinoic acid (ATRA)

46
Q

Bortezomib MOA

A

proteasome inhibitor; intercellular build up of unfolded proteins leads to cell death

47
Q

Bortezomib treats

A

multiple myeloma

48
Q

bortezemib side effects

A

peripheral neuropathy, myelosuppression, GI upset

Block 8 drugs (12 decks)

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