Chemotherapeutics: Alkylating Agents and Platinum Compounds

Question 1

Nitrogen Mustards MOA

Answer 1

forms DNA cross-links (attaches alkyl group to guanine and #7 nitrogen) , thus inhibiting dna synthesis and function

Question 2

Nitrogen mustards side effect

Answer 2

myelosuppression, immunosuppression, alopecia, n/v/d, mutagenic, carcinogenic, and teratogenic.

Question 3

Mecholorethamine (nitrogen mustard) treats

Answer 3

hodgekin’s lymphoma

Question 4

Chlorambucil (nitrogen mustard) treats

Answer 4

Chronic lymphocytic leukemia (CLL)

Question 5

Melphalan (nitrogen mustard) treats

Answer 5

CLL

Question 6

cyclophosphamide (nitrogen mustard) treats

Answer 6

lymphomas and breast cancer

Question 7

cyclophosphamide is a prodrug true/false

Answer 7

true, must be activated by CYP450 enzymes

Question 8

cyclophosphamide additional side effects

Answer 8

neurotoxicity, veno-occlusive dz, hemorrhagic cystitis (bladder)

Question 9

Ifosfamide (nitrogen mustard) treats

Answer 9

lymphomas and breast cancer

Question 10

Ifosfamide is a prodrug true/false

Answer 10

true, must be activated by CYP450 enzymes

Question 11

ifosfamide additional side effects

Answer 11

neurotoxicity, veno-occlusize dz, hemorrhagic cystitis (bladder)

Question 12

Busulfan (nitrogen mustard) treats

Answer 12

CML and depletes bone marrow for BMT

Question 13

bulsan additional side effects

Answer 13

pulmonary fibrosis

Question 14

Nitrosoureas MOA

Answer 14

forms DNA cross-links, thus inhibiting DNA synthesis and function

Question 15

nitrosoureas side effects

Answer 15

myelosuppression, immunosuppression, alopecia, n/v, mutagenic, carcinogenic, and teratogenic

Question 16

-Mustine is a suffix for what

Answer 16

nitrosoureas

Question 17

streptozotocin (nitrosoureas) treats

Answer 17

pancreatic cancer

Question 18

streptozotocin additional side effects

Answer 18

diabetic complications

Question 19

streptozotocin unique properties

Answer 19

minimal bone marrow toxicity and can cross BBB

Question 20

Carmustine treats

Answer 20

Brain and CNS

Question 21

carmustine additional side effects

Answer 21

delayed myelosuppression, renal and pulmonary fibrosis

Question 22

carmustine unique properties

Answer 22

crosses BBB

Question 23

Lomustine treats

Answer 23

Brain and CNS

Question 24

Lomustine addtional side effects

Answer 24

delayed myelosuppression, renal and pulmonary fibrosis

Question 25

lomustine unique properties

Answer 25

crosses BBB

Question 26

-platin is suffix for what

Answer 26

platinum compounds

Question 27

cisplatine MOA

Answer 27

crosslinks DNA resulting in inhibition of DNA and RNA synthesis (same for all platinum compounds)

Question 28

Cisplatine treats

Answer 28

testicular, ovarian and bladder cancers (same for all platinum compounds)

Question 29

Cisplatin side effects

Answer 29

n/v, nephrotoxcity, ototoxicity, some neurotoxicity and myelosuppression

Question 30

list platinum compounds from most toxic to least toxic

Answer 30

cisplatin>carboplatin>oxaliplatin

Question 31

caroboplatin and oxaliplatin additional side effect

Answer 31

skin rashes

Question 32

Dacarbazine is a

Answer 32

Imidazole

Question 33

Dacarabazine MOA

Answer 33

methylates DNA and inhibits dna synth and function

Question 34

dacarbazine side effects

Answer 34

immunosuppression, myelosuppression, alopecia, n/v, hepatoxicity, mutagenic, carcinogenic, teratogenic

Question 35

temozolomide is a

Answer 35

triazene

Question 36

temozolomide MOA

Answer 36

methylates DNA

Question 37

temozolomide treats

Answer 37

Brain and CNS

Question 38

temozolomide side effects

Answer 38

myelosuppression, immunosuppression, alopecia, n/v, hepatotoxicity, mutagenic, carcinogenic, teratogenic.