Glucocorticoids/Adrenal Hormones Flashcards
Glucocorticoid MOA
glucocorticoid receptor agonist, regulates gene transcription
Mineralcorticoid MOA
mineralcorticoid receptor agonist increases sodium and water retention
Cortisol uses
hormone replacement, inflammation, immunosuppression, topical applications
glucocorticoid side effects
hyperglycemia, fluid retention, risk of infection, myopathy, osteoporosis, doesn’t cure diseases that occur in episodes, must be withdrawn gradually
Prednisone MOA
glucocorticoid agonist
prednisone treats
hormone replacement, inflammation, immunosuppression
beclomethasone MOA
glucocorticoid agonist
beclomethasone treats
asthma
beclomethasone side effects
inhaled: sore throat, cough, runny nose
dexamethasone MOA
glucocorticoid agonist
dexamethasone treats
hormone replacement, inflammation, immunosuppression
dexamethasone unique properties
25x more potent than cortisol
fludrocortisone MOA
mineralcorticoid agonist
fludrocortisone treats
hormone replacement for adrenal insufficiency
fludrocortisone side effects
slow wound healing, dry skin, sweating, headache, dizziness
metryrapone MOA
inhibits final step of corticosteroid synthesis
metryrapone treats
cushing syndrome
metryrapone side effects
fatigue, n/v, don’t use in pts with adrenal insufficiency
ketoconazole MOA
inhibits first step of steroid hormone synthesis
ketoconazole treats
cushing syndrome
ketoconazole side effects
fatigue, n/v and loss of other hormones, CYP3A4
ketoconazole unique properties
inhibits all steroid horone synth at therapeutic dose
spironolactone MOA
mineralcorticoid antagonist
spironolactone treats
HTN
spironolactone side effects
v/d, dry mouth, dizziness, anuria, acute renal insufficiency, hyperkalemia
Eplerenone MOA
mineralcorticoid antagonist
eplerenone treats
HTN
eplerenone side effects
diarrhea, dizziness, fatigue, hyperkalemia
