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Block 8 drugs > Glucocorticoids/Adrenal Hormones > Flashcards

Glucocorticoids/Adrenal Hormones Flashcards

1
Q

Glucocorticoid MOA

A

glucocorticoid receptor agonist, regulates gene transcription

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2
Q

Mineralcorticoid MOA

A

mineralcorticoid receptor agonist increases sodium and water retention

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3
Q

Cortisol uses

A

hormone replacement, inflammation, immunosuppression, topical applications

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4
Q

glucocorticoid side effects

A

hyperglycemia, fluid retention, risk of infection, myopathy, osteoporosis, doesn’t cure diseases that occur in episodes, must be withdrawn gradually

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5
Q

Prednisone MOA

A

glucocorticoid agonist

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6
Q

prednisone treats

A

hormone replacement, inflammation, immunosuppression

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7
Q

beclomethasone MOA

A

glucocorticoid agonist

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8
Q

beclomethasone treats

A

asthma

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9
Q

beclomethasone side effects

A

inhaled: sore throat, cough, runny nose

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10
Q

dexamethasone MOA

A

glucocorticoid agonist

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11
Q

dexamethasone treats

A

hormone replacement, inflammation, immunosuppression

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12
Q

dexamethasone unique properties

A

25x more potent than cortisol

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13
Q

fludrocortisone MOA

A

mineralcorticoid agonist

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14
Q

fludrocortisone treats

A

hormone replacement for adrenal insufficiency

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15
Q

fludrocortisone side effects

A

slow wound healing, dry skin, sweating, headache, dizziness

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16
Q

metryrapone MOA

A

inhibits final step of corticosteroid synthesis

17
Q

metryrapone treats

A

cushing syndrome

18
Q

metryrapone side effects

A

fatigue, n/v, don’t use in pts with adrenal insufficiency

19
Q

ketoconazole MOA

A

inhibits first step of steroid hormone synthesis

20
Q

ketoconazole treats

A

cushing syndrome

21
Q

ketoconazole side effects

A

fatigue, n/v and loss of other hormones, CYP3A4

22
Q

ketoconazole unique properties

A

inhibits all steroid horone synth at therapeutic dose

23
Q

spironolactone MOA

A

mineralcorticoid antagonist

24
Q

spironolactone treats

A

HTN

25
Q

spironolactone side effects

A

v/d, dry mouth, dizziness, anuria, acute renal insufficiency, hyperkalemia

26
Q

Eplerenone MOA

A

mineralcorticoid antagonist

27
Q

eplerenone treats

A

HTN

28
Q

eplerenone side effects

A

diarrhea, dizziness, fatigue, hyperkalemia

Block 8 drugs (12 decks)

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