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Block 8 drugs > Immunomodulatory Drugs > Flashcards

Immunomodulatory Drugs Flashcards

1
Q

Cyclosporine MOA

A

calcineurin inhibition in complex with cyclophilin, inhibition of IL-2 transcription, reduced T cell response

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2
Q

cyclosporine treats

A

GVHD, organ transplant, RA

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3
Q

cyclosporine side effects

A

immunosuppression, renal toxicity, tremors, seizures, CYP3A4

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4
Q

tacrolimus (FK506) MOA

A

calcineurin inhibition in complex with FKBP, inhibit IL-2 transcrip, reduced t cell response

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5
Q

tacrolimus treats

A

GVHD, organ transplant, RA

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6
Q

tacrolimus side effects

A

immunosuppression, renal toxicity, tremors/seizures, diabetes, CYP3A4

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7
Q

Sirolimus is also called

A

rapamycin

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8
Q

sirolimus MOA

A

mTOR inhibition, inhibit IL-2 Trans, reduced T cell response

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9
Q

sirolimus treats

A

kidney transplant

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10
Q

sirolimus side effects

A

renal dysfunction, hyperlipidemia, myelosuppression (when used in combo with cyclosporine), CYP3A4

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11
Q

azathioprine treats

A

organ transplant and RA

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12
Q

mycophenolate mofetil is a ______

A

prodrug

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13
Q

mycophenolate mofetil MOA

A

inhibits inosine monophosphate DH (IMPDH), inhibits proliferations of B and T cells.

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14
Q

mycophenolate mofetil treats

A

organ transplant

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15
Q

methotrexate treats

A

RA and cancer chemotherapy

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16
Q

Prednisone MOA

A

glucocorticoid

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17
Q

prednisone treats

A

Organ transplant, RA, oncology

18
Q

prednisone side effects

A

HTN, fluid retention and restlessness

19
Q

Lenalidomide MOA

A

inhibits cereblon E3 ubiquintin ligase, suppresses cytokines

20
Q

lenalidomide treats

A

multiple myeloma

21
Q

lenalidomide side effects

A

neuropathy, DVT, teratogenicity (very high in pregnancy)

22
Q

lenalidomide unique properties

A

2nd generation IMiD

23
Q

Infliximab MOA

A

anti-TNF alpha mab

24
Q

Infliximab treats

A

RA and crohn’s disease

25
Q

infliximab side effects

A

serious infections

26
Q

what is infliximab often combined with

A

MTX

27
Q

Etanecerpt MOA

A

TNF alpha decoy receptor

28
Q

etanercept treats

A

RA

29
Q

etanercept side effect

A

serious infections

30
Q

etanercept is usually used with

A

MTX

31
Q

rituximab treats

A

B cell lymphomas and RA

32
Q

Ipillimumab MOA

A

anti-CTLA-4 mab (immune checkpoint inhibitor)

33
Q

Ipillimumab treats

A

melanoma

34
Q

Ipillimumab side effects

A

autoimmune-like and enterocolitis, rash, hepatotoxicity

35
Q

Pembrolizumab treats

A

melanoma, NSCLC, Head and neck cancers

36
Q

nivolumab works the same as

A

pembrolizumab

37
Q

Sargramostim MOA

A

recombinant human GM-CSF, stimulates differentiation of monocytes and neutrophils

38
Q

sargramostim treats

A

AIDS and chemo related neutropenia

39
Q

sargramostim side effects

A

bone pain

40
Q

Filgrastim MOA

A

recombinant G-CSF, stimulates differentiation of neutrophils

41
Q

filgrastim treats

A

neutropenia in AIDS and chemo pts

42
Q

filgrastim side effects

A

bone bane, rare cutaneous necrotizing vasculitis

Block 8 drugs (12 decks)

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