Immunomodulatory Drugs

Question 1

Cyclosporine MOA

Answer 1

calcineurin inhibition in complex with cyclophilin, inhibition of IL-2 transcription, reduced T cell response

Question 2

cyclosporine treats

Answer 2

GVHD, organ transplant, RA

Question 3

cyclosporine side effects

Answer 3

immunosuppression, renal toxicity, tremors, seizures, CYP3A4

Question 4

tacrolimus (FK506) MOA

Answer 4

calcineurin inhibition in complex with FKBP, inhibit IL-2 transcrip, reduced t cell response

Question 5

tacrolimus treats

Answer 5

GVHD, organ transplant, RA

Question 6

tacrolimus side effects

Answer 6

immunosuppression, renal toxicity, tremors/seizures, diabetes, CYP3A4

Question 7

Sirolimus is also called

Answer 7

rapamycin

Question 8

sirolimus MOA

Answer 8

mTOR inhibition, inhibit IL-2 Trans, reduced T cell response

Question 9

sirolimus treats

Answer 9

kidney transplant

Question 10

sirolimus side effects

Answer 10

renal dysfunction, hyperlipidemia, myelosuppression (when used in combo with cyclosporine), CYP3A4

Question 11

azathioprine treats

Answer 11

organ transplant and RA

Question 12

mycophenolate mofetil is a ______

Answer 12

prodrug

Question 13

mycophenolate mofetil MOA

Answer 13

inhibits inosine monophosphate DH (IMPDH), inhibits proliferations of B and T cells.

Question 14

mycophenolate mofetil treats

Answer 14

organ transplant

Question 15

methotrexate treats

Answer 15

RA and cancer chemotherapy

Question 16

Prednisone MOA

Answer 16

glucocorticoid

Question 17

prednisone treats

Answer 17

Organ transplant, RA, oncology

Question 18

prednisone side effects

Answer 18

HTN, fluid retention and restlessness

Question 19

Lenalidomide MOA

Answer 19

inhibits cereblon E3 ubiquintin ligase, suppresses cytokines

Question 20

lenalidomide treats

Answer 20

multiple myeloma

Question 21

lenalidomide side effects

Answer 21

neuropathy, DVT, teratogenicity (very high in pregnancy)

Question 22

lenalidomide unique properties

Answer 22

2nd generation IMiD

Question 23

Infliximab MOA

Answer 23

anti-TNF alpha mab

Question 24

Infliximab treats

Answer 24

RA and crohn’s disease

Question 25

infliximab side effects

Answer 25

serious infections

Question 26

what is infliximab often combined with

Answer 26

MTX

Question 27

Etanecerpt MOA

Answer 27

TNF alpha decoy receptor

Question 28

etanercept treats

Answer 28

RA

Question 29

etanercept side effect

Answer 29

serious infections

Question 30

etanercept is usually used with

Answer 30

MTX

Question 31

rituximab treats

Answer 31

B cell lymphomas and RA

Question 32

Ipillimumab MOA

Answer 32

anti-CTLA-4 mab (immune checkpoint inhibitor)

Question 33

Ipillimumab treats

Answer 33

melanoma

Question 34

Ipillimumab side effects

Answer 34

autoimmune-like and enterocolitis, rash, hepatotoxicity

Question 35

Pembrolizumab treats

Answer 35

melanoma, NSCLC, Head and neck cancers

Question 36

nivolumab works the same as

Answer 36

pembrolizumab

Question 37

Sargramostim MOA

Answer 37

recombinant human GM-CSF, stimulates differentiation of monocytes and neutrophils

Question 38

sargramostim treats

Answer 38

AIDS and chemo related neutropenia

Question 39

sargramostim side effects

Answer 39

bone pain

Question 40

Filgrastim MOA

Answer 40

recombinant G-CSF, stimulates differentiation of neutrophils

Question 41

filgrastim treats

Answer 41

neutropenia in AIDS and chemo pts

Question 42

filgrastim side effects

Answer 42

bone bane, rare cutaneous necrotizing vasculitis