NSAIDS and Gout drugs Flashcards
Acetylesalicylic acid trade name
Aspirin
Acetylsalicylic acid MOA
acetylation of active site serine; irreversible inhibition of COX-1
Aspirin treats
antiinflammatory, anti-pyreticc, analgesic
aspirin side effects
GI bleedings, salicylism, inhibits platelet aggregation
what is salicylism
tinnitus, n/v/d, transient hearing loss. this is dose related
Indomethacin MOA
non-selective COX-1/2 inhibitor
Indomethacin treats
anti-inflammatory, anti-pyretic, analgesic
indomethacin side effects
n/d, anorexia, abdom. pain, peptic ulcers, bleeding, headache, na/water retention, edema, aplastic anemia
indomethacin unique properties
headaches unique to this NSAID, risk for heart attack and stroke
Naproxen MOA
non selective COX-1/2 inhibitor
naproxen treats
anti-inflammatory, anti-pyretic and analgesic
naproxen side effects
peptic ulcers, bleeding, risk for heart attack and stroke
Ibuprofen MOA
non-selective COX1/2 inhibitor
ibuprofen treats
anti-inflammatory, anti-pyretic, analgesic
ibuprofen side effects
peptic ulcers, bleeding, risk for heart attack and stroke
ibuprofen unique properties
used to close patent ductus arteriosus
celecoxib MOA
COX-2 selective NSAID
celecoxib treats
anti-inflammatory, anti-pyretic, analgeisc in pts with history of peptic ulcers
celecoxib side effects
can lead to hypertension and/or MI due to PGI1 reduction in absence of reducing TXA2, black box warning for cardiac complications
celecoxib unique properties
lack of TXA2 while reducing PGI2 levels is a key attribute of COX2 selectivity leading to black box warning
sodium salicylate MOA
blocks transcription of COX2
sodium salicylate treats
anti-inflammatory, anti-pyretic, and analgesic
sodium salicylate side effects
may alter ag-ab interactions
sodium salicylate unique properties
for pts who can’t take NSAIDS, no effect on plate aggregation
acetaminophen MOA
weak COX1/2 inhibitor in the periphery, primarily acts in CNS
acetaminophen treats
analgesic, anti-pyretic
acetaminophen side effects
hepatotoxic due to GSH depletion-NAPQI accumulation
Probenecid MOA
uricosuric drug; competes with uric acid biding to OAT in proximal tubule, blocks uric acid reabsorption
probenecid treats
hyperurecemia and gout; adjunct to penicillin therapy
probenecid side effects
few side effects; primarily n/d, gouty attack
probenecid unique properties
originally developed to delay excretion of penecillin
Allopurinol MOA
xanthine oxidase inhibitor
allopurinol treats
hyperuricemia and gout
allopurinol side effect
characteristic rash
febuxostat MOA
non-purine based XO inhibitor
febuxostat treats
hyperuricemia and gout
febuxostat side effects
liver function abnormalties, nausea, joint pain, rash
allopurinol unique properties
originally an anti cancer drug
febuxostat unique properties
decreases uric acid precipitation and no dosage adjust required for reduced renal function
colchicine MOA
microtubule transport inhibitor; blocks PMN migration and inflammatory mediator release
colchicine treats
acute phase treatment of gout
colchicine side effects
n/v/d, cramping
