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Block 8 drugs > NSAIDS and Gout drugs > Flashcards

NSAIDS and Gout drugs Flashcards

1
Q

Acetylesalicylic acid trade name

A

Aspirin

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2
Q

Acetylsalicylic acid MOA

A

acetylation of active site serine; irreversible inhibition of COX-1

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3
Q

Aspirin treats

A

antiinflammatory, anti-pyreticc, analgesic

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4
Q

aspirin side effects

A

GI bleedings, salicylism, inhibits platelet aggregation

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5
Q

what is salicylism

A

tinnitus, n/v/d, transient hearing loss. this is dose related

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6
Q

Indomethacin MOA

A

non-selective COX-1/2 inhibitor

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7
Q

Indomethacin treats

A

anti-inflammatory, anti-pyretic, analgesic

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8
Q

indomethacin side effects

A

n/d, anorexia, abdom. pain, peptic ulcers, bleeding, headache, na/water retention, edema, aplastic anemia

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9
Q

indomethacin unique properties

A

headaches unique to this NSAID, risk for heart attack and stroke

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10
Q

Naproxen MOA

A

non selective COX-1/2 inhibitor

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11
Q

naproxen treats

A

anti-inflammatory, anti-pyretic and analgesic

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12
Q

naproxen side effects

A

peptic ulcers, bleeding, risk for heart attack and stroke

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13
Q

Ibuprofen MOA

A

non-selective COX1/2 inhibitor

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14
Q

ibuprofen treats

A

anti-inflammatory, anti-pyretic, analgesic

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15
Q

ibuprofen side effects

A

peptic ulcers, bleeding, risk for heart attack and stroke

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16
Q

ibuprofen unique properties

A

used to close patent ductus arteriosus

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17
Q

celecoxib MOA

A

COX-2 selective NSAID

18
Q

celecoxib treats

A

anti-inflammatory, anti-pyretic, analgeisc in pts with history of peptic ulcers

19
Q

celecoxib side effects

A

can lead to hypertension and/or MI due to PGI1 reduction in absence of reducing TXA2, black box warning for cardiac complications

20
Q

celecoxib unique properties

A

lack of TXA2 while reducing PGI2 levels is a key attribute of COX2 selectivity leading to black box warning

21
Q

sodium salicylate MOA

A

blocks transcription of COX2

22
Q

sodium salicylate treats

A

anti-inflammatory, anti-pyretic, and analgesic

23
Q

sodium salicylate side effects

A

may alter ag-ab interactions

24
Q

sodium salicylate unique properties

A

for pts who can’t take NSAIDS, no effect on plate aggregation

25
Q

acetaminophen MOA

A

weak COX1/2 inhibitor in the periphery, primarily acts in CNS

26
Q

acetaminophen treats

A

analgesic, anti-pyretic

27
Q

acetaminophen side effects

A

hepatotoxic due to GSH depletion-NAPQI accumulation

28
Q

Probenecid MOA

A

uricosuric drug; competes with uric acid biding to OAT in proximal tubule, blocks uric acid reabsorption

29
Q

probenecid treats

A

hyperurecemia and gout; adjunct to penicillin therapy

30
Q

probenecid side effects

A

few side effects; primarily n/d, gouty attack

31
Q

probenecid unique properties

A

originally developed to delay excretion of penecillin

32
Q

Allopurinol MOA

A

xanthine oxidase inhibitor

33
Q

allopurinol treats

A

hyperuricemia and gout

34
Q

allopurinol side effect

A

characteristic rash

35
Q

febuxostat MOA

A

non-purine based XO inhibitor

36
Q

febuxostat treats

A

hyperuricemia and gout

37
Q

febuxostat side effects

A

liver function abnormalties, nausea, joint pain, rash

38
Q

allopurinol unique properties

A

originally an anti cancer drug

39
Q

febuxostat unique properties

A

decreases uric acid precipitation and no dosage adjust required for reduced renal function

40
Q

colchicine MOA

A

microtubule transport inhibitor; blocks PMN migration and inflammatory mediator release

41
Q

colchicine treats

A

acute phase treatment of gout

42
Q

colchicine side effects

A

n/v/d, cramping

Block 8 drugs (12 decks)

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