NSAIDS and Gout drugs Flashcards
Acetylesalicylic acid trade name
Aspirin
Acetylsalicylic acid MOA
acetylation of active site serine; irreversible inhibition of COX-1
Aspirin treats
antiinflammatory, anti-pyreticc, analgesic
aspirin side effects
GI bleedings, salicylism, inhibits platelet aggregation
what is salicylism
tinnitus, n/v/d, transient hearing loss. this is dose related
Indomethacin MOA
non-selective COX-1/2 inhibitor
Indomethacin treats
anti-inflammatory, anti-pyretic, analgesic
indomethacin side effects
n/d, anorexia, abdom. pain, peptic ulcers, bleeding, headache, na/water retention, edema, aplastic anemia
indomethacin unique properties
headaches unique to this NSAID, risk for heart attack and stroke
Naproxen MOA
non selective COX-1/2 inhibitor
naproxen treats
anti-inflammatory, anti-pyretic and analgesic
naproxen side effects
peptic ulcers, bleeding, risk for heart attack and stroke
Ibuprofen MOA
non-selective COX1/2 inhibitor
ibuprofen treats
anti-inflammatory, anti-pyretic, analgesic
ibuprofen side effects
peptic ulcers, bleeding, risk for heart attack and stroke
ibuprofen unique properties
used to close patent ductus arteriosus
celecoxib MOA
COX-2 selective NSAID
celecoxib treats
anti-inflammatory, anti-pyretic, analgeisc in pts with history of peptic ulcers
celecoxib side effects
can lead to hypertension and/or MI due to PGI1 reduction in absence of reducing TXA2, black box warning for cardiac complications
celecoxib unique properties
lack of TXA2 while reducing PGI2 levels is a key attribute of COX2 selectivity leading to black box warning
sodium salicylate MOA
blocks transcription of COX2
sodium salicylate treats
anti-inflammatory, anti-pyretic, and analgesic
sodium salicylate side effects
may alter ag-ab interactions
sodium salicylate unique properties
for pts who can’t take NSAIDS, no effect on plate aggregation
