Chemotherapeutics: Antitumor Antibiotics, Topoisomerase Inhibitors and Antimitotics

Question 1

Bleomycin MOA

Answer 1

binds to DNA and produces free radicals that cleave DNA (single and double strand breaks)

Question 2

what phase does Bleomycin arrest cell in

Answer 2

G2

Question 3

bleomycin side effects

Answer 3

pulmonary fibrosis (bleomycin lung, can be fatal) and alopecia

Question 4

another name for Dactinomycin

Answer 4

Actinomycin D

Question 5

Dactinomycin MOA

Answer 5

intercalates DNA, blocks transcription and causes DNA strand breaks

Question 6

Dactinomycin treats

Answer 6

peds sarcomas

Question 7

dactinomycin side effects

Answer 7

immunosupression, myelosuppression, N/V

Question 8

-rubicin suffix is for

Answer 8

anthracyclines

Question 9

anthracyclines MOA

Answer 9

intercalates DNA, blocks RNA & DNA synthesis, causes DNA strand breaks following free radical formation.

Question 10

anthracyclines side effects

Answer 10

cardiotoxicity/cardiomyopathy (from free radicals), myelosuppression, n/v, alopecia

Question 11

doxorubicin unique properties

Answer 11

can cause red urine (not hematuria)

Question 12

Anti-tumor antibiotics can cross BBB true/flase

Answer 12

False

Question 13

daunorubicin unique properties

Answer 13

limited efficacy in solid tumors

Question 14

idrarubicin treats

Answer 14

leukemias

Question 15

idarubucin unique properties

Answer 15

daunorubicin analog; commonly used in combo with cytarabine in come leukemias

Question 16

Topoisomerase II inhibitors

Answer 16

etoposide

Question 17

Topoisomerase I inhibitors

Answer 17

topotecan and irinotecan

Question 18

Blocks S-G2 transition

Answer 18

Etoposide

Question 19

Blocks S phase

Answer 19

irinotecan and topotecan

Question 20

etoposide treats

Answer 20

lung and testicular cancer

Question 21

etoposide side effects

Answer 21

myelosuppression and alopecia

Question 22

irinotecan treats

Answer 22

colorectal carcinoma

Question 23

irinotecan side effects

Answer 23

myelosuppression and diarrhea

Question 24

topotecan is 1st or 2nd line treatment

Answer 24

2nd

Question 25

topotecan side effects

Answer 25

myelosuppression

Question 26

vinca alkaloids

Answer 26

vinblastine (vbl), vincristine (vx), vinorelbine (vrb)

Question 27

vinca alkaloids MOA

Answer 27

inhibit tubulin polymerization which is required for mitosis

Question 28

vinblastine (VBL) treats

Answer 28

testicular cancer and lymphomas

Question 29

vinblastine side effects

Answer 29

phlebitis, cellulitis, n/v, myelosuppression

Question 30

vincristine side effects

Answer 30

peripheral neuropathy, neurotoxicity, and constipation

Question 31

vinorelbine (VRB) treats

Answer 31

lung cancer

Question 32

vinorelbine side effects

Answer 32

granulocytopenia

Question 33

-taxel suffix for

Answer 33

taxanes

Question 34

taxanes MOA

Answer 34

stabilizes microtubules, prevents depolymerization and blocks progression in mitosis

Question 35

Taxanes treat

Answer 35

ovarian, breast, and lung cancers

Question 36

taxane side effects are

Answer 36

neutropenia, peripheral neuropathy, alopecia, fluid retention, and hypersensitivity

Question 37

taxane drugs

Answer 37

docetaxel and paclitaxel