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Block 8 drugs > Chemotherapeutics: Antitumor Antibiotics, Topoisomerase Inhibitors and Antimitotics > Flashcards

Chemotherapeutics: Antitumor Antibiotics, Topoisomerase Inhibitors and Antimitotics Flashcards

1
Q

Bleomycin MOA

A

binds to DNA and produces free radicals that cleave DNA (single and double strand breaks)

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2
Q

what phase does Bleomycin arrest cell in

A

G2

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3
Q

bleomycin side effects

A

pulmonary fibrosis (bleomycin lung, can be fatal) and alopecia

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4
Q

another name for Dactinomycin

A

Actinomycin D

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5
Q

Dactinomycin MOA

A

intercalates DNA, blocks transcription and causes DNA strand breaks

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6
Q

Dactinomycin treats

A

peds sarcomas

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7
Q

dactinomycin side effects

A

immunosupression, myelosuppression, N/V

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8
Q

-rubicin suffix is for

A

anthracyclines

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9
Q

anthracyclines MOA

A

intercalates DNA, blocks RNA & DNA synthesis, causes DNA strand breaks following free radical formation.

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10
Q

anthracyclines side effects

A

cardiotoxicity/cardiomyopathy (from free radicals), myelosuppression, n/v, alopecia

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11
Q

doxorubicin unique properties

A

can cause red urine (not hematuria)

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12
Q

Anti-tumor antibiotics can cross BBB true/flase

A

False

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13
Q

daunorubicin unique properties

A

limited efficacy in solid tumors

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14
Q

idrarubicin treats

A

leukemias

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15
Q

idarubucin unique properties

A

daunorubicin analog; commonly used in combo with cytarabine in come leukemias

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16
Q

Topoisomerase II inhibitors

17
Q

Topoisomerase I inhibitors

A

topotecan and irinotecan

18
Q

Blocks S-G2 transition

19
Q

Blocks S phase

A

irinotecan and topotecan

20
Q

etoposide treats

A

lung and testicular cancer

21
Q

etoposide side effects

A

myelosuppression and alopecia

22
Q

irinotecan treats

A

colorectal carcinoma

23
Q

irinotecan side effects

A

myelosuppression and diarrhea

24
Q

topotecan is 1st or 2nd line treatment

25
Q

topotecan side effects

A

myelosuppression

26
Q

vinca alkaloids

A

vinblastine (vbl), vincristine (vx), vinorelbine (vrb)

27
Q

vinca alkaloids MOA

A

inhibit tubulin polymerization which is required for mitosis

28
Q

vinblastine (VBL) treats

A

testicular cancer and lymphomas

29
Q

vinblastine side effects

A

phlebitis, cellulitis, n/v, myelosuppression

30
Q

vincristine side effects

A

peripheral neuropathy, neurotoxicity, and constipation

31
Q

vinorelbine (VRB) treats

A

lung cancer

32
Q

vinorelbine side effects

A

granulocytopenia

33
Q

-taxel suffix for

34
Q

taxanes MOA

A

stabilizes microtubules, prevents depolymerization and blocks progression in mitosis

35
Q

Taxanes treat

A

ovarian, breast, and lung cancers

36
Q

taxane side effects are

A

neutropenia, peripheral neuropathy, alopecia, fluid retention, and hypersensitivity

37
Q

taxane drugs

A

docetaxel and paclitaxel

Block 8 drugs (12 decks)

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