Rh System C and E ags

Question 1

Anti-A Anti-B Anti-D AI cell B cell
+4 0 +4 0 +4

Interpretation?

Answer 1

A pos

Question 2

Anti-A Anti-B Anti-D AI cell B cell
0 0 0 +4 +4

Interpretation
What do you do with 0 Anti-D

Answer 2

O neg
AI null gene
H/H homozygous
d/d homozygous

With the negative Anti D use AHG to confirm rxn

Question 3

RhD is?

Answer 3

polymorphic

Question 4

Another word for Partial D?
where is it located?

Answer 4

D-mosaic
located outside of the cell

Question 5

Where is Weak D located?

Answer 5

Inside the cell

Question 6

Describe Rh Null

causes?

Rh null regulator

Rh null amorph

Answer 6

Rh deficiency syndrome

Rh Null regulator: absence of RhAg regulator does not place Rh ag onto the cell.

Rh null amorph: Rh genes genetically mutated to missence genes

Question 7

Symptoms of Rh null

Answer 7

chronic hem anemia, stomatocyte/sphero
overactive ATPase

Question 8

Serology of Rh null
lack of?
reduced?

Answer 8

lack of Rh Ag (may or may not have rhag)
Lack LW and FY5: reduced expression of SsU

Question 9

Describe C ag
apart of?
mutations?
hybrid?

Answer 9

antitethical ag: C or c
apart of RHCE
Mutations in caucasions C ag

RHDII-CE hybrid expresses no D ag

Question 10

C frequency in
White
Black
Chinese
Indian
Hispanic

Answer 10

W: 70
B: 30
C: 90
I: 85
H: 70

Question 11

c frequency in
White
black
chinese
indian
hispanic

who is it most likely in?

Answer 11

w: 80
b: 96
c: 60
i: 50
h: 40

Question 12

C antibody briefly described
what kind of ig
stimulation
causes?
morphology?

Answer 12

IgG
immune stimulated
Anti-c is next immunogenic
can cause HDN
in pairs

Question 13

Immunogenicity rankings from D

Answer 13

D>c>E>C>e

Question 14

Describe the E ag
most common
high

E ab
more
stim?

Answer 14

antethetical E and e
most common mutation on e
high incidence Ag

Ab: E more immunogenic
immune stimulated

Question 15

E frequency in W/B/C/I/H

e frequency

Answer 15

E
W: 30
B 20
C 50
I 20
H 25

e
w 100
b 100
c 90
i 100
h 80

Question 16

Is e or E more frequent?

Answer 16

e

Question 17

Anti-D Anti-C Anti-c Anti-E Anti-e
+4 +3 0 +4 +3

What ag are present on the Rbcs?
what ab can they make?

Answer 17

DCEe
controlls are screen cells
phenotype Rh

they can make Anti-c Ab

Question 18

Describe Ficher-Race

Answer 18

medelian inheritence of Co-dom expressed Ag
3 genes = 3 ags closely linked
Named: DCcEe

Question 19

Describe Weiner

Answer 19

mend. inhert. co-dom expressed Ag
3 alleles from a single locus on a gene
Named: Rh0, hr’,hr’’

Question 20

Describe Tippett

Answer 20

2 genes on chrom 1
RHD for D and RHCE for Ce 1

Question 21

Describe the translation of these names to Weiners

DCe
DcE
Dce
dce

Answer 21

DCe - R1
DcE - R2
Dce - R0
dce -Rz

Question 22

Describe the translation of these names to Weiners

dCe
dcE
dce
dCE

Answer 22

dCe -r’
dcE - r’’
dce - r (most common)
dCE- ry (rare)

Question 23

Describe C ag
capellini effect

Answer 23

When paured w/ D on same haplotype, condiminish D expression “c in trans” capellini efect

DCe/dCe
R1

Question 24

Frequencies of
D
e
c
C
E
lower in which ethnicities?

Answer 24

D - 85 low white
e - 98
c - 80 low asian
C -70 low black
E - 30

Question 25

T/F abx reactions are stronger with homozygous

Answer 25

true

Question 26

What is the equation for # of units to test

Answer 26

units to test = 100 x # units needed / % compatibility

Question 27

% compatibility equation

Answer 27

100-Ag frequency

Question 28

Predict the genotype
Anti-D Anti-C Anti-c Anti-E Anti-e
+4 0 +3 +3 +3

Answer 28

DcE/Dce

Question 29

Combo Ab
Anti-f

Answer 29

ce on same haplotype (compound) c-units compatible

Question 30

Combo Ab
Anti-G

Answer 30

D or C doesnt matter which
matters for Rhogam not transfusion

Question 31

Concominant Ab
Anti-c and Anti-E
Anti D
Anti -C

Answer 31

Anti-c + Anti-E togehter DCe common haplotype
Anti-D may have Anti-G
Anti-C is often found w/ Anti-D
Anti-F is often found w Anti-C

Question 32

D–

causes

Answer 32

Deletion Ag
D expression is enhanced “exalted” D can make Rh-17

Causes: RHD disrupts RHCE more D expressed/transcribed

RHCE silencer (hispanics)

Question 33

How many genes are in Rh

Answer 33

two genes plus rhag