AB ID Flashcards
At immediate spin there is +2 reactivity in SCI and SCII but none is SC3, at 37 degrees SCI/SCII are now at +1 reactivty, AHG there is no reactivity confirmed by AHG. What is this ab?
Igm Antibody clinically significant
What must you check for?
do what control?
allo and auto anitbodies
do an autocontrol with 3% and plasma
Clinically significant anitbodies definition and example
react at body temp and destroy ag+ rbcs
hemolytic transfusions or HDN
example Anti-M
Alloantibody
preventable
pt missing Ag
transfuse compatible cells
Autoantibody
unrelated to transfusion
pt has ag
transfuse only as necessary
Autocontrol
self vs self
plasma vs rbc
Phenotype
self vs ab
rbc vs known substance
Ab-ID
self vs cell
plasma vs cells
Low incidence Ag
presence in less than 10% of the population, ab rare because likelyhood of exposure is low
High incidence Ag
present in greater than 90% of the population, ab rare becasue pt being able to make ab is low
High titer low avidity Ab (HTLA)
nus
weak,big,blcoks
doesnt cause
nuisance ab
weak reactivity, big titer, block ab from being apparent
dont cause HDN/TFR
Chido/rodgers are neutralized by?
ab neutralized by plasma
JMH ag destroyed by
enzymes
Ab Titer
specific test to diagnose
ab titer remove so underlying allo-ab can be detected
First steps
blood type/phenotype/ABO AB ID
