Autoimmune hemolytic anemias Flashcards
Allo-immune
Auto-Immune
Drug induced
allo immune- outside stim
Auto immune- Attacking self
Drug induced - consequence of treatment
Immune anemias cause the destruction of…
rbcs and metabolism of products of destruction
Alloimmune causes
HTR, HDN
Autoimmune causes
c,p,w
CAS, PCH, WAIHA
Drug induced
dependent?
a?
d?
hapten dependent, auto, drug dependent
IgM
messes with?
what binds?
messes w reverse type (at room temp)
ABO binds compliment
Anemia classification
Class, compliment, strength, immune activation, titer….etc
First differentiating factor in autoimmune hem anemias
warm vs cold
Warm anemias overview
temp?
what may bind?
DAT rxn?
A?
extra?
Frequently?
Symptoms?
more in?
> 32 degrees
IgG may bind
DAT: IgG+ C3+/-
AHG
Extravascular
Frequently Rh
exhausted/anemic
more in the summer
Cold anemias overview
temp?
what class?
rxn?
spin?
hemolysis?
frequently?
extremities?
more in?
<30 degrees
IgM binds compliment
IgG - C3+
IS
Intra/extra
Frequently I or P
purple extremities
more in winter
Cold Rxn Antibodies
Benign
common?
low?
enhanced with?
ig class?
Anti?
most common
low titer
enhanced with alb/enzymes
IgM
Anti-I, IH or i
Cold rxn Antibodies
Pathogenic
common?
high?
enhanced with?
class?
Anti?
not common
high titer >1000
enhanced with alb/enzymes
IgM
Anti-I, P or M
Benign cold agglutinins
Anti-I
Anti- i
Anti- IH
Anti- I : doesnt react with cord rbcs
Anti- i: doesnt react w/ adult rbc
Anti-IH: doesnt react w/ AI, B or AB rbcs
Precursors
to developing….
to developing other autooimmune disorders like lupus, titer 0 cells <65
T/F pre-warm IS crossmatch and reverse type
ture