Blood Groups Pt 2

Question 1

MNS system
2nd…
ags
presence?

S frequency population

Answer 1

2nd place, discovery complex

2nd most complex system next to Rh

M,N,s,S,U

Ag present at birth

S not frequent in black/asian (most likely ab)

Question 2

MNS system rbc substance
what subtance containing on rbc
g.a

long
target for?

Answer 2

sialic containing substance on rbc, glycophorin A (N-terminal ag)

long chain passes through rbc once
influenza target/plasmodium falciparum

Question 3

En(a-)

Answer 3

lack of GYPA/B

Question 4

Anti-N
found?
what kind of pts?

Answer 4

not frequently found
found in dialysis pts

Question 5

Anti-M
found? N
compliment?
rxn? (Ig)
special feature?

Answer 5

frequently found
naturally occuring
NO COMPLIMENT
cold rxn
dosage

Question 6

Enzymatic variable on MNS
what is negatively charged on rbcs?

less…than… developed at birth

Answer 6

glycophorin B negative charge on rbcs (s/S)

less B than A chains well developed at birth

Question 7

Anti-S
s
what may bind?
special features/significance?

Answer 7

immune stimulated
IgG may bind
dosage
HDN
warm reactive

Question 8

Anti-U
u
ig?
clinical siginficance?
common?
an?

Answer 8

immune stim
IgG
HDN/TFXR
Rare no antethetical

Question 9

MK-
U-
Ena-

Answer 9

Mk- null for MNS system
U- absense of glyco B
Ena - absence of glyco A

Question 10

P system

Answer 10

P1 most common - fully functional transferases (P1/P/PK ag)

P2 lacks P1 ag still has P and Pk

p null rare makes complex ab Anti-ppIpk (spontaneous miscarages)

Question 11

P1pk
galacto

Answer 11

galactosyltransferase

Question 12

Pk ag
precursor
not serologically detected unless?

Answer 12

precursor to P
not serologically detected unless p =

Question 13

P1 ag
expression?
population frequency?
deterorates with?

Answer 13

not expressed at birth
more in the black population
detereorates w storage

Question 14

I and i ag are apart of?

Answer 14

H2 precursor for ABO

Question 15

Glob 28

Answer 15

acetylgalactos

Question 16

p ag
receptor for?
development?
highest ag?

Answer 16

receptor for parvo virus
well developed at birth
highest ag density to any ag

Question 17

Lke ag
frequency?
rxn?
receptor for?
named after?

Answer 17

high frequency
variable rxn
receptor for uropath e.coli
hodgkins lymphom pt named for

Question 18

I vs i
I
i

there is no…?
can be in?
most common rxn?

Answer 18

I branchy
i linear (fetal)

There is no I/i negative blood
can be in most fluids
cold rxn most common non-spec agglutination

Question 19

Auto-Anti-I

Auto-Anti-i

Answer 19

is in virtually all serum

auto-i: most common in lymphoprolieratives like mono, rxn strong w baby cells

Question 20

Anti-P1

Answer 20

naturally occuring Igm weak cold rxn

Question 21

Anti-p
what Ig
occurance?
what individuals
casues?

Answer 21

nat occuring pk individuals TFR not HDN IgM

Question 22

Anti-PIppk
what individuals
causes?
compliment relation?

Answer 22

naturally occuring in p (null) individuals spontaneous abortion, hemolysis
binds complimentD

Question 23

Donathan landsteiner

Answer 23

Anti-P associated w Cold prox hemoglobin in children

Question 24

Describe not as usual suspects

Answer 24

ag occurs so infrequently encounter is low
clinically insignificant or unknown significance

Question 25

Diego
ags? (d/w)

population

why is it not significant?

Answer 25

Dia
Dib (high freq)
wra
wrb (high freq)

dia south american indians
chemical/enzyme resistant

high freq/low freq pair

Question 26

Cartwright
what is the ags?
y
population?

why is it not clincially significant?

Answer 26

Yta (High freq)
Ytb

Ytb in isralies
sensitive to DTT
ACHE

high freq/low freq pair

Question 27

X linked

Answer 27

Xga Cd99
not clinically sign some cold
more common in females
sensitive to DTT

Question 28

Scianna

Answer 28

Sc1 (more)
Sc2
Sc3 null

unknown signiicance

Question 29

Dombrock
ags?

immunogenicity?

what population matches duffy?

Answer 29

Doa
Dob
gya

poor immunogenicity
caucasion population matches duffy

Question 30

Landsteiner weiner

Answer 30

lwa more
lwb
weak on D-

Question 31

Colton
ags?

significance?
transfer?
pair?

Answer 31

coa (more)
cob
co3 null

clin insignificant
HDN
high freq/low freq pair
water transfer

Question 32

Chido/rhogers
ags?

sigificance?
neutralized?

Answer 32

CH 1-6
rg 1-2

clin insign
compliment absorbed
neutralized by plasma

Question 33

Gerbich
ag
significant?
population?

Answer 33

Gel 4
clin sign
leach type in papua new guinea

Question 34

Cromer
high freq ags? (c/t/d)

destoryed by?

Answer 34

Cra Tca Dra (high freq)
tcb/tcc

Cra black
Dra japanese
destroyed by alpha-chymotrypsin

Question 35

Knops
ags? (k/mc/sl/v)

Answer 35

Kna mcCa sla/vii
not clin significant

Question 36

Ok

Answer 36

Oka
plasmodium falciparum
not immunogenic

Question 37

Indian
non clinical ..

Answer 37

Inb
sensitive to enzymes
high incidence/low incidence
HTR non clinical HDN

Question 38

Mer-z/RAPH

Answer 38

HTR
on plts/reduced in mature rbcs
8% mer neg

Question 39

JMH

Answer 39

clin insign old people

Question 40

Vel-VEL

Answer 40

variable expression
severe HDN
compliment

Question 41

JRa

Answer 41

common in japan
severe HDFN

Question 42

SDA

Answer 42

clinically insignificant
tamms-horsfall
not in newborn cells/in saliva
NEUTRALIZED BY URINE

Question 43

AnJW
auto?
receptor for
population

Answer 43

haemophilus influenza receptor
autoab
isreali women

Question 44

HLA

Answer 44

Bga/Bgb/Bgc
no HDN some HTR
resist to enzymes/DTT
neutralized by plt concentration